Evidence map›Paper›PMID 38332543›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Brain artery diameters and risk of dementia and stroke.

Jesus D Melgarejo, Kursat Gurel, Cassidy Rose Compton, Minghua Liu, Vanessa Guzman, Stephanie Assuras, Bonnie E Levin, Mitchell S V Elkind, M Kamran Ikram, Maryam Kavousi and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Brain artery diameters and risk of dementia and stroke.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 4 countries.

Jesus D MelgarejoDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.ORCID 0000-0002-1382-1153
Kursat GurelDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Cassidy Rose ComptonDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Minghua LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Vanessa GuzmanDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Stephanie AssurasDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Bonnie E LevinDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
M Kamran IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Clinton WrightNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Fabrice CrivelloInstitute of Neurodegenerative Diseases, UMR5293, Neurofunctional Imaging Group, Bordeaux, France.
Alexandre LaurentInstitute of Neurodegenerative Diseases, UMR5293, Neurofunctional Imaging Group, Bordeaux, France.
Christophe TzourioBordeaux Population Health Research Center, Inserm, University Bordeaux, Bordeaux, France.
Meike W VernooijDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Tatjana RundekDepartment of Public Health Sciences and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Zhen-Yu ZhangStudies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium.
Daniel BosDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Jose GutierrezDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Columbia University · USErasmus MC · NLInstitut des Maladies Neurodégénératives · FRUniversity of Miami · USInserm · FRKU Leuven · BENational Institutes of Health · US

Funding

Genetic Contribution to Brain Arterial Dilatation and its Role in Cognition and dementiaR01AG057709 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2018 to 2022
$4.6M
Accelerated non-atherosclerotic brain arterial aging relationship to Alzheimer's diseaseR01AG066162 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUTIERREZ, JOSE · 2019 to 2023
$3.1M
Vascular Determinants of Dementia and Cognitive Decline in a Tri-Ethnic RegionR56NS029993 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ELKIND, MITCHELL S, RUNDEK, TATJANA · 2021 to 2021
$537k
NIA NIH HHS R01 AG057709NIA NIH HHS R01 AG066162NINDS NIH HHS R56 NS029993
6 · The paper itself

Abstract

introductionWe tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.

methodsWe included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.

resultOverall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile. DISCUSSION: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.

Indexed as

DementiaStrokeAdultBasilar ArteryBrainHumansMagnetic Resonance ImagingRisk Factorsbrain artery diameterdementiamagnetic resonance imagingpopulation‐based sciencestroke

Identifiers

PMID38332543
PMCPMC11032539
OpenAlexW4391687045

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.