Evidence map›Paper›PMID 38331983›Full record

ArticleScientific reports2024

Dolutegravir based therapy showed CD4

Teshager Gebremedhin, Melak Aynalem, Mohammed Adem, Demeke Geremew, Yetemwork Aleka, Amare Kiflie

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Hidden risks of first-line regimen switching in antiretroviral therapy-treated patients.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Teshager GebremedhinUniversity of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia.
Melak AynalemDepartment of Hematology and Immunohematology, University of Gondar, Gondar, Ethiopia.
Mohammed AdemDepartment of Immunology and Molecular Biology, University of Gondar, Gondar, Ethiopia.
Demeke GeremewDepartment of Medical Laboratory Sciences, Immunology and Molecular Biology Unit, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Yetemwork AlekaDepartment of Immunology and Molecular Biology, University of Gondar, Gondar, Ethiopia. yetemnice@gmail.com.
Amare KiflieDepartment of Immunology and Molecular Biology, University of Gondar, Gondar, Ethiopia.
University of Gondar · ETBahir Dar University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, dolutegravir (DTG)-based combined therapy, a more effective and safer first-line antiretroviral therapy (ART), has been recommended by the World Health Organization for the treatment of Human Immunodeficiency Virus (HIV) since July 2018. However, its effectiveness in CD4

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsHeterocyclic Compounds, 3-RingHIV-1HIV InfectionsOxazinesPiperazinesPyridonesAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesDolutegravirHumansPilot ProjectsProspective StudiesRNAAnti-HIV AgentsDolutegravirHeterocyclic Compounds, 3-RingOxazinesPiperazinesPyridonesRNA

Identifiers

PMID38331983
PMCPMC10853173
OpenAlexW4391657616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.