Evidence map›Paper›PMID 38331982›Full record

ArticleBone marrow transplantation2024

Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study.

Olga Moser, Maud Ngoya, Jacques-Emmanuel Galimard, Arnaud Dalissier, Jean Hugues Dalle, Krzysztof Kalwak, Wilhelm Wössmann, Birgit Burkhardt, Marc Bierings, Marta Gonzalez-Vicent and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Bone marrow transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 18 institutions in 7 countries.

Olga MoserUniversity Hospital RWTH Aachen, Department of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Aachen, Germany. omoser@ukaachen.de.ORCID 0000-0002-2712-3145
Maud NgoyaEBMT Paris Office, Hôpital Saint Antoine, Paris, France.
Jacques-Emmanuel GalimardEBMT Paris Office, Hôpital Saint Antoine, Paris, France.ORCID 0000-0001-9102-4427
Arnaud DalissierEBMT Paris Office, Hôpital Saint Antoine, Paris, France.
Jean Hugues DalleHôpital Robert Debre Pediatric Hematology and Immunology Department, GHU APHP Nord Université Paris Cité, Paris, France.
Krzysztof KalwakDepartment of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw, Poland.ORCID 0000-0003-1174-5799
Wilhelm WössmannUniversity Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany.ORCID 0000-0002-6315-0888
Birgit BurkhardtPediatric Hematology, Oncology and BMT, University Hospital Münster, Münster, Germany.ORCID 0000-0002-1151-829X
Marc BieringsPrincess Maxima Center/ University Hospital for Children (WKZ), Utrecht, The Netherlands.ORCID 0000-0002-0192-3080
Marta Gonzalez-VicentNiño Jesus Children's Hospital, Stem cell transplant unit, Madrid, Spain.ORCID 0000-0002-4845-5616
Lucía López CorralHematology Department. Hospital Universitario de Salamanca (Spain), IBSAL, CIBERONC. Centro de Investigación del Cáncer-IBMCC (USAL-CSIC), Salamanca, Spain.
Karin MellgrenSahlgrenska University Hospital, Department of Pediatric Oncology, Göteborg, Sweden.
Andishe AttarbaschiSt. Anna Children's Hospital. Department of Pediatric Hematology and Oncology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9285-6898
Jean Henri BourhisDépartement d'Hématologie, Institut Gustave Roussy, Villejuif, France.
Kristina CarlsonUniversity Children's Hospital Dept. of Women's & Children's Health, Uppsala, Sweden.
Selim CorbaciogluUniversity Hospital Regensburg, Paediatric Haematology, Oncology and Stem Cell Transplantation, Regensburg, Germany.ORCID 0000-0003-1070-8486
Katarzyna DrabkoMedical University of Lublin, Dept. Pediatric Hematology, Oncology, and Transplantology, Lublin, Poland.
Mikael SundinKarolinska University Hospital Children's Hospital, Paediatric Haematology, Stockholm, Sweden.
Jacek ToporskiKarolinska University Hospital Children's Hospital, Paediatric Haematology, Stockholm, Sweden.
Gunnar CarioUniversity Medical Center Schleswig-Holstein Kiel, División of Stem Cell Transplantation and Immunotherapy, Kiel, Germany.
Udo KontnyUniversity Hospital RWTH Aachen, Department of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Aachen, Germany.ORCID 0000-0002-3072-6772
Sorbonne Université · FRKarolinska University Hospital · SEHospital Infantil Universitario Niño Jesús · ESInstitut Gustave Roussy · FRInstituto de Investigación Biomédica de Salamanca · ESMedical University of Lublin · PLPrincess Máxima Center · NLRWTH Aachen University · DESahlgrenska University Hospital · SESt Anna Children's Hospital · ATUniversität Hamburg · DEUniversitätsklinikum Aachen · DEUniversité Paris Cité · FRUniversity Hospital Münster · DEUniversity Hospital Regensburg · DEUniversity Hospital Schleswig-Holstein · DEUppsala University Hospital · SEWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of the European Society for Blood and Marrow Transplantation we analyzed 55 patients aged < 18 years who received allogeneic (N = 46) or autologous (N = 9) HSCT for PTCL. Median age at HSCT was 13.9 years; 33 patients (60%) were in first remission, and 6 (19%) in progression at HSCT. Conditioning was myeloablative in 87% of the allogeneic HSCTs and in 27 (58.7%) based on total body irradiation. After allogeneic HSCT the 5-year overall- and progression-free survival was 58.9% (95% CI 42.7-71.9) and 52.6% (95% CI 36.8-66.1), respectively. 5-year relapse incidence was 27.6% (95% CI 15.1-41.6), the non-relapse mortality rate was 19.8% (95% CI 9.7-32.6). Five of the six patients with progression at HSCT died. Seven of nine patients after autologous HSCT were alive and disease-free at last follow-up. Our data suggest a role of allogeneic HSCT in consolidation-treatment of patients with high-risk disease, who reach at least partial remission after primary- or relapse-therapy, whereas patients with therapy-refractory or progressive disease prior to transplantation do not profit from HSCT.

Indexed as

Hematopoietic Stem Cell TransplantationLymphoma, T-Cell, PeripheralAdolescentChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantMaleRetrospective StudiesSurvival RateTransplantation Conditioning

Identifiers

PMID38331982
PMCPMC11073963
OpenAlexW4391655947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.