ReviewSignal transduction and targeted therapy2024
Major depressive disorder: hypothesis, mechanism, prevention and treatment.
Review in Signal transduction and targeted therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 511 papers, 15 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Therapeutic Drug Monitoring-Guided Treatment With Sertraline, or Escitalopram in Hospitalized Adults and Children
Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Undergoing Non-cardiac Surgery: a Two-center, Dose-exploring Pilot Trial
Effect of Psilocybin and Structured Integrated Reframing Therapy on Gut-Brain Axis Biomarkers and Depression in Trauma-Related Major Depressive Disorder: Randomized Controlled Trial
Who cites it
511 citing papers in PubMed, 15 syntheses or guidelines pooled it.
- Isolated physical activity programs during pregnancy and postpartum: Meta-analysis of randomized trials with usual-care controls on depressive and anxiety symptoms.Archives of women's mental health · 2026Pooled it
- Multimodal microglial and kynurenine pathway alterations across the affective-psychosis spectrum: a systematic review of patterns, heterogeneity, and dimensional implications.Molecular psychiatry · 2026Pooled it
- Interleukin-1β (C-511T) Genetic Variant and Major Depressive Disorder: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Pooled it
- Therapeutic effects of psilocybin in major depressive disorder: a systematic review and meta-analysis exploring dose effects.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Machine Learning for Comparative Antidepressant Selection in Major Depressive Disorder: Systematic Review.JMIR mental health · 2026Pooled it
- Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review.Molecular psychiatry · 2026Pooled it
- Association of IL-6 rs1800795 (- 174G > C) polymorphism with depression risk: a comprehensive meta-analysis.Scientific reports · 2026Pooled it
- Systems-level transcriptomic analysis reveals synapse-related gene dysregulation in peripheral leukocytes of MDD patients.Scientific reports · 2026Pooled it
- Blood circulating cell-free mitochondrial DNA as a potential biomarker for major depressive disorder: a meta-analysis.Translational psychiatry · 2026Pooled it
- Is the antidepressant efficacy of ketamine and esketamine mediated via opioid mechanisms?European psychiatry : the journal of the Association of European Psychiatrists · 2026Pooled it
- Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis.NeuroImage. Clinical · 2026Pooled it
- Aberrations in Peripheral Blood Neuron-Specific Enolase Levels in Depression: A Systematic Review and Meta-Analysis.Depression and anxiety · 2026Pooled it
- Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2026Pooled it
- Efficacy of repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy for depression: a systematic review and meta-analysis.Frontiers in psychology · 2026Pooled it
- Preparing for future pandemics: enhancing serotonin activation and interpersonal warmth through music therapy to aid in adolescent depression recovery post-COVID-19: a randomized controlled trial.BMC complementary medicine and therapies · 2026Trial
- Exploring blood-based biomarkers in late-life depression: Correlates of psychotherapeutic treatment outcomes.European psychiatry : the journal of the Association of European Psychiatrists · 2026Trial
- The Impact of an Economic Empowerment Intervention on Economic Security among AIDS-Orphaned Adolescents in Southern Uganda: the Moderating Role of Depression.AIDS and behavior · 2026Trial
- Behavioural, neurochemical, and neurohistological effects of bisphenol A and vanadium following chronic co-administration in mice.IBRO neuroscience reports · 2026Article
- Patients With Atypical Symptoms of Depression Respond Better to Lithium Augmentation Than Patients Without Atypical Symptoms.Acta psychiatrica Scandinavica · 2026Article
451 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, the pathological mechanisms of MDD and the mechanisms underlying the effects of pharmacological treatments for MDD are complex and unclear, and additional diagnostic and therapeutic strategies for MDD still are needed. The currently widely accepted theories of MDD pathogenesis include the neurotransmitter and receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis hypothesis, cytokine hypothesis, neuroplasticity hypothesis and systemic influence hypothesis, but these hypothesis cannot completely explain the pathological mechanism of MDD. Even it is still hard to adopt only one hypothesis to completely reveal the pathogenesis of MDD, thus in recent years, great progress has been made in elucidating the roles of multiple organ interactions in the pathogenesis MDD and identifying novel therapeutic approaches and multitarget modulatory strategies, further revealing the disease features of MDD. Furthermore, some newly discovered potential pharmacological targets and newly studied antidepressants have attracted widespread attention, some reagents have even been approved for clinical treatment and some novel therapeutic methods such as phototherapy and acupuncture have been discovered to have effective improvement for the depressive symptoms. In this work, we comprehensively summarize the latest research on the pathogenesis and diagnosis of MDD, preventive approaches and therapeutic medicines, as well as the related clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.