Evidence map›Paper›PMID 38331971›Full record

ArticleNature communications2024

A 3D printable tissue adhesive.

Sarah J Wu, Jingjing Wu, Samuel J Kaser, Heejung Roh, Ruth D Shiferaw, Hyunwoo Yuk, Xuanhe Zhao

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Catechol Derivative-Based Bioadhesives: Molecular Design for Precision Medical Adhesion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Biodegradable Adhesive Systems for Bio-Integrated Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Multifunctional Fluorescent Microgel-Embedded Hydrogels for Temperature and X-Ray Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J WuDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Jingjing WuDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-4565-6914
Samuel J KaserDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Heejung RohDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0003-2436-8742
Ruth D ShiferawDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Hyunwoo YukDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. hyunwooyuk@sanaheal.com.ORCID 0000-0003-1710-9750
Xuanhe ZhaoDepartment of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. zhaox@mit.edu.ORCID 0000-0001-5387-6186

Funding

Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
Atraumatic Non-fibrotic Epicardial Pacing with E-Bioadhesive DevicesR01HL167947 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Leigh Gareth Griffiths, Christoph Gunther Stanislaw Nabzdyk · 2023 to 2026
$2.4M
NHLBI NIH HHS R01 HL153857NHLBI NIH HHS R01 HL167947
6 · The paper itself

Abstract

Tissue adhesives are promising alternatives to sutures and staples for joining tissues, sealing defects, and immobilizing devices. However, existing adhesives mostly take the forms of glues or hydrogels, which offer limited versatility. We report a direct-ink-write 3D printable tissue adhesive which can be used to fabricate bioadhesive patches and devices with programmable architectures, unlocking new potential for application-specific designs. The adhesive is conformable and stretchable, achieves robust adhesion with wet tissues within seconds, and exhibits favorable biocompatibility. In vivo rat trachea and colon defect models demonstrate the fluid-tight tissue sealing capability of the printed patches, which maintained adhesion over 4 weeks. Moreover, incorporation of a blood-repelling hydrophobic matrix enables the printed patches to seal actively bleeding tissues. Beyond wound closure, the 3D printable adhesive has broad applicability across various tissue-interfacing devices, highlighted through representative proof-of-concept designs. Together, this platform offers a promising strategy toward developing advanced tissue adhesive technologies.

Indexed as

Tissue AdhesivesAdhesivesAnimalsHydrogelsRatsTechnologyAdhesivesHydrogelsTissue Adhesives

Identifiers

PMID38331971
PMCPMC10853267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.