Evidence map›Paper›PMID 38331945›Full record

ArticleNature communications2024

Contribution of climate change to the spatial expansion of West Nile virus in Europe.

Diana Erazo, Luke Grant, Guillaume Ghisbain, Giovanni Marini, Felipe J Colón-González, William Wint, Annapaola Rizzoli, Wim Van Bortel, Chantal B F Vogels, Nathan D Grubaugh and 4 more

Registry-linked trialAbstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07094724 (High-titer West Nile Virus-neutralizing Plasma for Hospitalized Patients With West Nile Fever), which is not on this map. Cited by 82 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07094724 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

High-titer West Nile Virus-neutralizing Plasma for Hospitalized Patients With West Nile Fever: a Prospective Controlled Clinical Study Using Historical Controls

TypeinterventionalSponsorGili Regev-Yochay MDRan2025 to 2025Enrolled37ConditionsWest Nile FeverArmsPlasma
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Modelling the risk of West Nile virus infection in seven European countries from published serological and case notification data, 2008 to 2022.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Diana ErazoSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium. diana.erazo.quintero@ulb.be.ORCID 0000-0002-9726-9502
Luke GrantDepartment of Water and Climate, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0003-0636-2806
Guillaume GhisbainSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium.
Giovanni MariniResearch and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.ORCID 0000-0001-9721-7211
Felipe J Colón-GonzálezData for Science and Health, Wellcome Trust, London, UK.
William WintEnvironmental Research Group Oxford Ltd, Department of Biology, Mansfield Road, Oxford, OX1 3SZ, UK.ORCID 0000-0003-0916-0847
Annapaola RizzoliResearch and Innovation Centre, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.
Wim Van BortelUnit Entomology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.ORCID 0000-0002-6644-518X
Chantal B F VogelsDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0003-0027-6480
Nathan D GrubaughDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA.ORCID 0000-0003-2031-1933
Matthias MengelDepartment Transformation Pathways, Potsdam Institute for Climate Impact Research (PIK), Potsdam, Germany.
Katja FrielerDepartment Transformation Pathways, Potsdam Institute for Climate Impact Research (PIK), Potsdam, Germany.ORCID 0000-0003-4869-3013
Wim ThieryDepartment of Water and Climate, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0002-5183-6145
Simon DellicourSpatial Epidemiology Lab (SpELL), Université Libre de Bruxelles, Brussels, Belgium. simon.dellicour@ulb.be.ORCID 0000-0001-9558-1052

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

West Nile virus (WNV) is an emerging mosquito-borne pathogen in Europe where it represents a new public health threat. While climate change has been cited as a potential driver of its spatial expansion on the continent, a formal evaluation of this causal relationship is lacking. Here, we investigate the extent to which WNV spatial expansion in Europe can be attributed to climate change while accounting for other direct human influences such as land-use and human population changes. To this end, we trained ecological niche models to predict the risk of local WNV circulation leading to human cases to then unravel the isolated effect of climate change by comparing factual simulations to a counterfactual based on the same environmental changes but a counterfactual climate where long-term trends have been removed. Our findings demonstrate a notable increase in the area ecologically suitable for WNV circulation during the period 1901-2019, whereas this area remains largely unchanged in a no-climate-change counterfactual. We show that the drastic increase in the human population at risk of exposure is partly due to historical changes in population density, but that climate change has also been a critical driver behind the heightened risk of WNV circulation in Europe.

Indexed as

CulicidaeWest Nile FeverWest Nile virusAnimalsClimate ChangeEuropeHumans

Identifiers

PMID38331945
PMCPMC10853512

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.