Evidence map›Paper›PMID 38331924›Full record

Trial reportScientific reports2024

Longitudinal changes in brain metabolites following pediatric concussion.

Parker L La, Robyn Walker, Tiffany K Bell, William Craig, Quynh Doan, Miriam H Beauchamp, Roger Zemek, Keith Owen Yeates, Ashley D Harris, Pediatric Emergency Research Canada A-CAP study team

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Parker L LaDepartment of Radiology, University of Calgary, Calgary, AB, Canada. parker.la@ucalgary.ca.
Robyn WalkerDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Tiffany K BellDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
William CraigDepartment of Pediatrics, Stollery Children's Hospital, University of Alberta, Edmonton, AB, Canada.
Quynh DoanDepartment of Pediatrics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.
Miriam H BeauchampDepartment of Psychology, Ste Justine Hospital Research Centre, University of Montreal, Montreal, QC, Canada.
Roger ZemekDepartment of Pediatrics and Emergency Medicine, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, ON, Canada.
Keith Owen YeatesDepartment of Psychology, University of Calgary, Calgary, AB, Canada.
Ashley D HarrisDepartment of Radiology, University of Calgary, Calgary, AB, Canada.
Pediatric Emergency Research Canada A-CAP study team
University of Calgary · CAUniversité de Montréal · CAAlberta Children's Hospital · CAUniversity of Alberta · CAUniversity of British Columbia · CAUniversity of Ottawa · CAAlberta Health Services · CA

Funding

CIHR FDN143304
6 · The paper itself

Abstract

Concussion is commonly characterized by a cascade of neurometabolic changes following injury. Magnetic Resonance Spectroscopy (MRS) can be used to quantify neurometabolites non-invasively. Longitudinal changes in neurometabolites have rarely been studied in pediatric concussion, and fewer studies consider symptoms. This study examines longitudinal changes of neurometabolites in pediatric concussion and associations between neurometabolites and symptom burden. Participants who presented with concussion or orthopedic injury (OI, comparison group) were recruited. The first timepoint for MRS data collection was at a mean of 12 days post-injury (n = 545). Participants were then randomized to 3 (n = 243) or 6 (n = 215) months for MRS follow-up. Parents completed symptom questionnaires to quantify somatic and cognitive symptoms at multiple timepoints following injury. There were no significant changes in neurometabolites over time in the concussion group and neurometabolite trajectories did not differ between asymptomatic concussion, symptomatic concussion, and OI groups. Cross-sectionally, Choline was significantly lower in those with persistent somatic symptoms compared to OI controls at 3 months post-injury. Lower Choline was also significantly associated with higher somatic symptoms. Although overall neurometabolites do not change over time, choline differences that appear at 3 months and is related to somatic symptoms.

Indexed as

Brain ConcussionMedically Unexplained SymptomsBrainChildCholineHumansMagnetic Resonance SpectroscopyCholine

Identifiers

PMID38331924
PMCPMC10853495
OpenAlexW4391653674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.