ArticleCardiovascular diabetology2024
Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism.
Article in Cardiovascular diabetology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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110 citing papers in PubMed, 116 citations in OpenAlex.
- Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review.Cardiovascular endocrinology & metabolism · 2026Review
- A CVD Classification Model for Individuals With Obesity: Multi-Ethnic Validation Based on Multiple Metabolic Indicators.Obesity (Silver Spring, Md.) · 2026Article
- Non-traditional lipid-inflammatory parameters estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study.Journal of advanced research · 2026Article
- Synergistic effect of AIP and cystatin C: a study on cardiovascular risk prediction in populations with different glycemic statuses.Diabetology & metabolic syndrome · 2026Article
- Atherogenic index of plasma and risk of hypertensive disorders of pregnancy in women with gestational diabetes mellitus: a two-center cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Observational
- Association of the atherogenic index of plasma and its integrative novel adiposity-based composites with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome: novel adiposity-derived AIP indices provide modest incremental prognostic information.Cardiovascular diabetology · 2026Article
- Joint association of high-sensitivity C-reactive protein and cumulative atherogenic index of plasma with cardiovascular disease risk in CKM syndrome stages 0-3: a prospective cohort study.BMC cardiovascular disorders · 2026Article
- Cumulative visceral fat burden and progression to advanced cardiovascular kidney metabolic syndrome in Chinese middle-aged and older adults.Scientific reports · 2026Article
- Association between the atherogenic index of plasma trajectory and risk of cardiovascular diseases among hypertensive patients: a prospective cohort study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- The Association Between Plasma Atherogenic Index Control Level and the Onset of Hypertension in Chinese Children and Adolescents.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Non-traditional metabolic indices predict incident circadian syndrome in middle-aged and older Chinese adults: a nationwide prospective cohort study and machine learning analysis.Lipids in health and disease · 2026Observational
- Article
- Atherogenic index of plasma in early pregnancy: associations with gestational diabetes mellitus and preeclampsia and its mediating role.Lipids in health and disease · 2026Article
- Association of cumulative exposure and change patterns of triglyceride-glucose index combined with novel obesity indices with glycemic transitions in prediabetes: evidence from the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Observational
- Association between cumulative TyG/AIP-derived indices and terminal survival time in older patients with circulatory system diseases.BMC geriatrics · 2026Article
- Lipid profile dynamics and associated cardiovascular disease risk indices in Chinese people living with human immunodeficiency virus receiving antiretroviral therapy.BMC infectious diseases · 2026Article
- Longitudinal cohort study on the dynamic changes of atherogenic index of plasma and the risk of cardiometabolic multimorbidity in middle - aged and elderly people.BMC cardiovascular disorders · 2026Article
- The joint association of the combined triglyceride-glucose index and atherogenic index of plasma with hypertension on stroke risk across different glycemic status: a prospective cohort study.Cardiovascular diabetology · 2026Article
- Atherogenic Index of Plasma and Residual Risk in Anticoagulated Patients With Atrial Fibrillation: The Prospective Murcia Atrial Fibrillation Project III Cohort.Journal of the American Heart Association · 2026Article
- Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis.Cardiovascular diabetology · 2026Article
50 more citing papers are in PubMed but not listed here.
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13 authors at 3 institutions in 1 country.
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Abstract
backgroundThe atherogenic index of plasma (AIP) and cardiovascular disease (CVD) in participants with abnormal glucose metabolism have been linked in previous studies. However, it was unclear whether AIP control level affects the further CVD incidence among with diabetes and pre-diabetes. Therefore, our study aimed to investigate the association between AIP control level with risk of CVD in individuals with abnormal glucose metabolism.
methodsParticipants with abnormal glucose metabolism were included from the China Health and Retirement Longitudinal Study. CVD was defined as self-reporting heart disease and/or stroke. Using k-means clustering analysis, AIP control level, which was the log-transformed ratio of triglyceride to high-density lipoprotein cholesterol in molar concentration, was divided into five classes. The association between AIP control level and incident CVD among individuals with abnormal glucose metabolism was investigated multivariable logistic regression analysis and application of restricted cubic spline analysis.
results398 (14.97%) of 2,659 participants eventually progressed to CVD within 3 years. After adjusting for various confounding factors, comparing to class 1 with the best control of the AIP, the OR for class 2 with good control was 1.31 (95% CI, 0.90-1.90), the OR for class 3 with moderate control was 1.38 (95% CI, 0.99-1.93), the OR for class 4 with worse control was 1.46 (95% CI, 1.01-2.10), and the OR for class 5 with consistently high levels was 1.56 (95% CI, 1.03-2.37). In restricted cubic spline regression, the relationship between cumulative AIP index and CVD is linear. Further subgroup analysis demonstrated that the similar results were observed in the individuals with agricultural Hukou, history of smoking, diastolic blood pressure ≥ 80mmHg, and normal body mass index. In addition, there was no interaction between the AIP control level and the subgroup variables.
conclusionsIn middle-aged and elderly participants with abnormal glucose metabolism, constant higher AIP with worst control may have a higher incidence of CVD. Monitoring long-term AIP change will contribute to early identification of high risk of CVD among individuals with abnormal glucose metabolism.
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