Evidence map›Paper›PMID 38329927›Full record

ArticlePLoS computational biology2024

Multiscale networks in multiple sclerosis.

Keith E Kennedy, Nicole Kerlero de Rosbo, Antonio Uccelli, Maria Cellerino, Federico Ivaldi, Paola Contini, Raffaele De Palma, Hanne F Harbo, Tone Berge, Steffan D Bos and 27 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS computational biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 7 institutions in 6 countries.

Keith E KennedyDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0001-5551-7304
Nicole Kerlero de RosboDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Antonio UccelliDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Maria CellerinoDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Federico IvaldiDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Paola ContiniDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Raffaele De PalmaDepartment of Neurology, Ospedale Policlinico San Martino-IRCCS and Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa Italy.
Hanne F HarboDepartment of Neurology, University of Oslo, Oslo, Norway.
Tone BergeDepartment of Neurology, Oslo University Hospital, Oslo, Norway.
Steffan D BosDepartment of Neurology, University of Oslo, Oslo, Norway.
Einar A HøgestølDepartment of Neurology, University of Oslo, Oslo, Norway.ORCID 0000-0001-8446-2111
Synne Brune-IngebretsenDepartment of Neurology, University of Oslo, Oslo, Norway.
Sigrid A de Rodez BenaventDepartment of Neurology, University of Oslo, Oslo, Norway.
Friedemann PaulDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Alexander U BrandtDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Priscilla Bäcker-KoduahDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Janina BehrensDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Joseph KuchlingDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Susanna AsseyerDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Michael ScheelDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Claudia ChienDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.ORCID 0000-0001-8280-9513
Hanna ZimmermannDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Seyedamirhosein MotamediDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Josef Kauer-BoninDepartment of Neurology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Julio Saez-RodriguezInstitute for Computational Biomedicine, University of Heidelberg, Heidelberg, Germany.
Melanie RinasInstitute for Computational Biomedicine, University of Heidelberg, Heidelberg, Germany.
Leonidas G AlexopoulosProtATonce Ltd, Athens, Greece.
Magi AndorraCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Sara LlufriuCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Albert SaizCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Yolanda BlancoCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Eloy Martinez-HerasCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Elisabeth SolanaCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Irene Pulido-ValdeolivasCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Elena H Martinez-LapiscinaCenter of Neuroimmunology, Hospital Clinic Barcelona, and Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain.
Jordi Garcia-OjalvoDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-3716-7520
Pablo VillosladaDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain.ORCID 0000-0002-8735-6119
Humboldt-Universität zu Berlin · DEOslo University Hospital · NOOspedale Policlinico San Martino · ITUniversitat Pompeu Fabra · ESHeidelberg University · DENational Technical University of Athens · GRUniversity of California, Irvine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex diseases such as Multiple Sclerosis (MS) cover a wide range of biological scales, from genes and proteins to cells and tissues, up to the full organism. In fact, any phenotype for an organism is dictated by the interplay among these scales. We conducted a multilayer network analysis and deep phenotyping with multi-omics data (genomics, phosphoproteomics and cytomics), brain and retinal imaging, and clinical data, obtained from a multicenter prospective cohort of 328 patients and 90 healthy controls. Multilayer networks were constructed using mutual information for topological analysis, and Boolean simulations were constructed using Pearson correlation to identified paths within and among all layers. The path more commonly found from the Boolean simulations connects protein MK03, with total T cells, the thickness of the retinal nerve fiber layer (RNFL), and the walking speed. This path contains nodes involved in protein phosphorylation, glial cell differentiation, and regulation of stress-activated MAPK cascade, among others. Specific paths identified were subsequently analyzed by flow cytometry at the single-cell level. Combinations of several proteins (GSK3AB, HSBP1 or RS6) and immune cells (Th17, Th1 non-classic, CD8, CD8 Treg, CD56 neg, and B memory) were part of the paths explaining the clinical phenotype. The advantage of the path identified from the Boolean simulations is that it connects information about these known biological pathways with the layers at higher scales (retina damage and disability). Overall, the identified paths provide a means to connect the molecular aspects of MS with the overall phenotype.

Indexed as

Multiple SclerosisBrainHeat-Shock ProteinsHumansProspective StudiesRetinaTomography, Optical CoherenceHeat-Shock ProteinsHSBP1 protein, human

Identifiers

PMID38329927
PMCPMC10852301
OpenAlexW4391655889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.