Evidence map›Paper›PMID 38329817›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3

Céline Legrand, Domien Vanneste, Alexandre Hego, Catherine Sabatel, Kiréna Mollers, Joey Schyns, Pauline Maréchal, Joan Abinet, Amandine Tytgat, Maude Liégeois and 6 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Single-Cell Insights Into Macrophage Subtypes in Pulmonary Infections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. The role of innate immune system in respiratory viral infection related asthma.Frontiers in cellular and infection microbiology · 2025
    Review
  9. Article
  10. Article
  11. Pulmonary Interstitial Macrophages stIMulate Regulatory T-Cell Responses.American journal of respiratory cell and molecular biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Céline LegrandLaboratory of Cellular and Molecular Immunology.
Domien VannesteLaboratory of Immunophysiology, and.
Alexandre HegoIn Vitro Imaging Platform, GIGA Institute, and.
Catherine SabatelLaboratory of Cellular and Molecular Immunology.
Kiréna MollersLaboratory of Cellular and Molecular Immunology.
Joey SchynsLaboratory of Cellular and Molecular Immunology.
Pauline MaréchalLaboratory of Immunophysiology, and.
Joan AbinetLaboratory of Immunophysiology, and.
Amandine TytgatLaboratory of Cellular and Molecular Immunology.
Maude LiégeoisLaboratory of Cellular and Molecular Immunology.
Barbara PoleseLaboratory of Cellular and Molecular Immunology.
Margot MeunierLaboratory of Immunophysiology, and.
Coraline RadermeckerLaboratory of Immunophysiology, and.
Laurence FiévezLaboratory of Cellular and Molecular Immunology.
Fabrice BureauLaboratory of Cellular and Molecular Immunology.
Thomas MarichalLaboratory of Immunophysiology, and.ORCID 0000-0003-1688-6291
University of Liège · BELaboratory of Molecular Genetics · PLIn Vitro Testing Industrial Platform · ES

Funding

Baillet Latour FundExcellence of ScienceH2020 European Research Council 801823
6 · The paper itself

Abstract

Lung macrophages constitute a sophisticated surveillance and defense system that contributes to tissue homeostasis and host defense and allows the host to cope with the myriad of insults and antigens to which the lung mucosa is exposed. As opposed to alveolar macrophages, lung interstitial macrophages (IMs) express high levels of Type 2 major histocompatibility complex (MHC-II), a hallmark of antigen-presenting cells. Here, we showed that lung IMs, like dendritic cells, possess the machinery to present soluble antigens in an MHC-II-restricted way. Using

Indexed as

Antigen PresentationAsthmaForkhead Transcription FactorsLungOvalbuminT-Lymphocytes, RegulatoryAnimalsAntigensCell ProliferationHistocompatibility Antigens Class IIInterleukin-10Lymphocyte ActivationMacrophagesMacrophages, AlveolarMiceMice, Inbred BALB CAntigensForkhead Transcription FactorsFoxp3 protein, mouseHistocompatibility Antigens Class IIInterleukin-10OvalbuminTransforming Growth Factor betaantigen presentationIL-10IMMHC-II

Identifiers

PMID38329817
OpenAlexW4391642459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.