Evidence map›Paper›PMID 38329811›Full record

ArticleOphthalmic epidemiology2024

Corneal pannus, Herbert's pits and conjunctival inflammation in older children in Papua New Guinea.

Gillian M Cochrane, Magdelene Mangot, Wendy Houinei, Melinda Susapu, Anasaini Cama, Richard Le Mesurier, Sara Webster, Tessa Hillgrove, Jaki Barton, Robert Butcher and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 6 countries.

Gillian M CochraneCollaborative Vision, Melbourne, Australia.
Magdelene MangotNational Prevention of Blindness Committee, Port Moresby, Papua New Guinea.
Wendy HouineiNational Department of Health, Port Moresby, Papua New Guinea.
Melinda SusapuNational Department of Health, Port Moresby, Papua New Guinea.
Anasaini CamaFred Hollows Foundation, Sydney, Australia.
Richard Le MesurierFred Hollows Foundation, Sydney, Australia.
Sara WebsterFred Hollows Foundation, Sydney, Australia.
Tessa HillgroveFred Hollows Foundation, Sydney, Australia.
Jaki BartonFred Hollows Foundation, Sydney, Australia.
Robert ButcherClinical Research Department, London School of Hygiene & Tropical Medicine, UK.
Emma M Harding-EschClinical Research Department, London School of Hygiene & Tropical Medicine, UK.ORCID 0000-0002-1432-8109
David MabeyClinical Research Department, London School of Hygiene & Tropical Medicine, UK.
Ana BakhtiariInternational Trachoma Initiative,Task Force for Global Health, Atlanta, USA.
Andreas MüllerDepartment of Noncommunicable Diseases, World Health Organization, Geneva, Switzerland.
Aya YajimaDivision of Programmes for Disease Control, Western Pacific Regional Office, World Health Organization, Manila, Philippines.
Anthony W SolomonGlobal Neglected Tropical Diseases Programme, World Health Organization, Geneva, Switzerland.
John KaldorKirby Institute, University of New South Wales, Sydney, Australia.
Samuel Peter KoimPNG Eye Care, Port Moresby, Papua New Guinea.
Robert KoNational Department of Health, Port Moresby, Papua New Guinea.
Jambi GarapNational Prevention of Blindness Committee, Port Moresby, Papua New Guinea.
National Department of Health · PGLondon School of Hygiene & Tropical Medicine · GBWorld Health Organization · CHInternational Trachoma Initiative · USPort Moresby General Hospital · PGUNSW Sydney · AUVision Australia · AUWorld Health Organization Regional Office for the Western Pacific · PH

Funding

World Health Organization 001
6 · The paper itself

Abstract

purposeThe prevalence of trachomatous inflammation-follicular (TF) in Papua New Guinea (PNG) suggests antibiotic mass drug administration (MDA) is needed to eliminate trachoma as a public health problem but the burden of trichiasis is low. As a result, WHO issued bespoke recommendations for the region. If ≥ 20% of 10-14-year-olds have both any conjunctival scarring (C1 or C2 or C3) and corneal pannus and/or Herbert's pits, MDA should be continued. Equally, if ≥ 5% of that group have both moderate/severe conjunctival scarring (C2 or C3) and corneal pannus and/or Herbert's pits, MDA should be continued.

methodsWe identified 14 villages where > 20% of 1-9-year-olds had TF during baseline mapping undertaken 4 years and 1 month previously. Every child aged 10-14 years in those villages was eligible to be examined for clinical signs of corneal pannus, Herbert's pits and conjunctival scarring. A grading system that built on existing WHO grading systems was used.

resultsOf 1,293 resident children, 1,181 (91%) were examined. Of 1,178 with complete examination data, only one (0.08%) individual had concurrent scarring and limbal signs.

conclusionsThe WHO-predefined criteria for continuation of MDA were not met. Ongoing behavioural and environmental improvement aspects of the SAFE strategy may contribute to integrated NTD control. Surveillance methods should be strengthened to enable PNG health authorities to identify future changes in disease prevalence.

Indexed as

TrachomaAdolescentChildChild, PreschoolConjunctivitisCorneal DiseasesFemaleHumansMalePapua New GuineaPrevalencecorneal limbusHerbert’s pitspannusPapua New GuineaTrachoma

Identifiers

PMID38329811
PMCPMC7618772
OpenAlexW4391655962

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.