Evidence map›Paper›PMID 38329694›Full record

ArticleHuman cell2024

Targeting cholesterol biosynthesis for AT/RT: comprehensive expression analysis and validation in newly established AT/RT cell line.

Fumitaka Matsumoto, Kiyotaka Yokogami, Ai Yamada, Hiroshi Moritake, Takashi Watanabe, Shinji Yamashita, Yuichiro Sato, Hideo Takeshima

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fumitaka MatsumotoDepartment of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan. fumitaka_matsumoto@med.miyazaki-u.ac.jp.
Kiyotaka YokogamiDepartment of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID http://orcid.org/0000-0003-1320-9383
Ai YamadaDivision of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroshi MoritakeDivision of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Takashi WatanabeDepartment of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Shinji YamashitaDepartment of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yuichiro SatoDivision of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hideo TakeshimaDepartment of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
University of Miyazaki · JP

Funding

JSPS KAKENHI 22K09262
6 · The paper itself

Abstract

Atypical teratoid/rhabdoid (AT/RT) is a rare and highly malignant tumor of the central nervous system (CNS). It is most commonly found in children less than 5 years of age and is associated with inactivation of loss of function of SMARCB1/INI1. An experimental model for AT/RT is necessary to develop new and effective therapies. We established a patient-derived new cell line (MZ611ATRT), which showed loss of BAF-47. MZ611ATRT genetically features somatic heterozygous deletion of SMARCB1 and single nucleotide deletion of the residual allele, exon 5 ([c.541delC]), resulting in a stop codon at codon 954 by frameshift. We assessed the RNA-sequencing data of the other two AT/RT cell lines with forced expression of SMARCB1 available from public databases. We found SMARCB1 overexpression significantly down-regulates the expression of a group of enzymes related to cholesterol biosynthesis. Simvastatin was highly sensitive against MZ611ATRT cells and induced apoptosis (IC

Indexed as

CholesterolCell LineChildExonsHumansCholesterolApoptosisAtypical teratoid/rhabdoid tumorCholesterol biosynthesisPatient-derived cell lineSimvastatin

Identifiers

PMID38329694
OpenAlexW4391646675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.