Evidence map›Paper›PMID 38329687›Full record

ArticleInfection2024

Burden of Candida-related vascular graft infection: a nested-case control study.

Thomas Caulier, Eric Senneville, Jonathan Sobocinski, Olivier Leroy, Pierre Patoz, Nicolas Blondiaux, Hugues Georges, Delannoy Pierre-Yves, PierVito d'Elia, Olivier Robineau

Abstract read
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Article in Infection, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Thomas CaulierService de Réanimation, CH de Tourcoing, France.
Eric SennevilleService Universitaire Des Maladies Infectieuses Et du Voyageur, Centre Hospitalier Gustave Dron, 59210, Tourcoing, France.
Jonathan SobocinskiService de Chirurgie Vasculaire, CHRU de Lille, Lille, France.
Olivier LeroyService de Réanimation, CH de Tourcoing, France.
Pierre PatozService de Biologie, CH de Tourcoing, France.
Nicolas BlondiauxService de Biologie, CH de Tourcoing, France.
Hugues GeorgesService de Réanimation, CH de Tourcoing, France.
Delannoy Pierre-YvesService de Réanimation, CH de Tourcoing, France.
PierVito d'EliaService de Chirurgie Vasculaire, CH de Tourcoing, France.
Olivier RobineauService Universitaire Des Maladies Infectieuses Et du Voyageur, Centre Hospitalier Gustave Dron, 59210, Tourcoing, France. olivier.robineau@univ-lille.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs).

methodsWe did a case-control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis.

results16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candida spp.-related VGIs [RRa 10.43 [1.81-60.21] p = 0.009 RRa and 6.46 [1.17-35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002).

conclusionsCandida-related VGIs are severe. Early markers of Candida spp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.

Indexed as

CandidiasisProsthesis-Related InfectionsAgedAged, 80 and overBlood Vessel ProsthesisCandidaCase-Control StudiesFemaleHumansMaleMiddle AgedRisk FactorsAortic endoprosthesisCandida albicansCase control studyOutcomeVascular graft infection

Identifiers

PMID38329687

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.