Evidence map›Paper›PMID 38329657›Full record

ArticleAnnals of surgical oncology2024

Gross Hematuria Does not Affect the Selection of Nephrectomy Types for Clinical Stage 1 Clear Cell Renal Cell Carcinoma: A Multicenter, Retrospective Cohort Study.

Zhuo Xing, Haozhe Xu, Kai Ai, Haitao Deng, Yulong Hong, Piye Deng, Jie Wang, Wei Xiong, Zhi Li, Lingfei Zhu and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhuo Xing *Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haozhe Xu *Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kai AiDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haitao DengDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yulong HongDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Piye DengDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jie WangHunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Wei XiongDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhi LiDepartment of Urology, The Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan, China.
Lingfei ZhuDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuan LiDepartment of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. yuanlixy@csu.edu.cn.ORCID http://orcid.org/0000-0002-5249-3172

Funding

National Natural Science Foundation of China 82172878National Natural Science Foundation of China 82373435
6 · The paper itself

Abstract

purposeThis study aimed to discuss the correlation between gross hematuria and postoperative upstaging (from T1 to T3a) in patients with cT1 clear cell renal cell carcinoma (ccRCC) and to compare oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) in patients with gross hematuria.

methodsA total of 2145 patients who met the criteria were enrolled in the study (including 363 patients with gross hematuria). The least absolute selection and shrinkage operator logistic regression was used to evaluate the risk factor of postoperative pathological upstaging. The propensity score matching (PSM) and stable inverse probability of treatment weighting (IPTW) analysis were used to balance the confounding factors. The Kaplan-Meier analysis and multivariate Cox proportional risk regression model were used to assess the prognosis.

resultsGross hematuria was a risk factor of postoperative pathological upstaging (odds ratio [OR] = 3.96; 95% confidence interval [CI] 2.44-6.42; P < 0.001). After PSM and stable IPTW adjustment, the characteristics were similar in corresponding patients in the PN and RN groups. In the PSM cohort, PN did not have a statistically significant impact on recurrence-free survival (hazard ratio [HR] = 1.48; 95% CI 0.25-8.88; P = 0.67), metastasis-free survival (HR = 1.24; 95% CI 0.33-4.66; P = 0.75), and overall survival (HR = 1.46; 95% CI 0.31-6.73; P = 0.63) compared with RN. The results were confirmed in sensitivity analyses.

conclusionsAlthough gross hematuria was associated with postoperative pathological upstaging in patients with cT1 ccRCC, PN should still be the preferred treatment for such patients.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsHematuriaHumansNeoplasm StagingNephrectomyRetrospective StudiesTreatment OutcomeClinical stage 1 clear cell renal cell carcinomaGross hematuriaInverse probability of treatment weightingLeast absolute selection and shrinkage operator logistic regressionNephrectomy typesPropensity score matching

Identifiers

PMID38329657

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.