Evidence map›Paper›PMID 38329630›Full record

ArticleMolecular biology reports2024

Hypoxia increases the biogenesis of IGF2BP3-bound circular RNAs.

Kriti Kaushik, Hemant Kumar, Samriddhi Mehta, Jayanth Kumar Palanichamy

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kriti KaushikDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, Convergence Block, New Delhi, 110029, India.ORCID http://orcid.org/0009-0007-2945-6799
Hemant KumarDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, Convergence Block, New Delhi, 110029, India.ORCID http://orcid.org/0009-0007-1071-1446
Samriddhi MehtaDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.ORCID http://orcid.org/0009-0003-2112-5937
Jayanth Kumar PalanichamyDepartment of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, Convergence Block, New Delhi, 110029, India. drjayanth@aiims.edu.ORCID http://orcid.org/0000-0002-3903-7252
All India Institute of Medical Sciences · INDepartment of Biotechnology · IN

Funding

DBT Research Associateship Indian Institute of Science DRF 42Department of Health and Research Young Scientist Award IMYS 07The Wellcome Trust DBT India Alliance IA/CPHE/15/1/502050
6 · The paper itself

Abstract

backgroundInsulin-like Growth Factor 2 Binding Protein 3 (IGF2BP3) promotes cancer migration and invasion by binding to several coding and non-coding RNAs. Hypoxia stimulates tumor progression by upregulating Hypoxia Inducible Factors and downstream signaling. Quaking (QKI) gene, which is upregulated in hypoxia and promotes epithelial to mesenchymal transition (EMT), induces circular RNAs. Therefore, the axis between IGF2BP3, QKI, circular RNAs and their respective host genes under hypoxia was studied. METHODS AND

resultsSeveral IGF2BP3-bound circular RNAs were previously identified in HepG2. There were 13 circRNAs originating from 8 host genes bound to IGF2BP3. We confirmed their binding to IGF2BP3 in U87MG using an RNA Immunoprecipitation assay. MALAT1, an oncogenic lncRNA was also found to be associated with IGF2BP3. Three adherent cell lines expressing high levels of IGF2BP3 viz., HeLa, HepG2 and U87MG were cultured under normoxia (20%O

conclusionOur data implies that hypoxia augments circRNA biogenesis which might subsequently play a role in tumor progression.

Indexed as

Epithelial-Mesenchymal TransitionRNA-Binding ProteinsRNA, CircularCell Transformation, NeoplasticHeLa CellsHumansRNA, MessengerIGF2BP3 protein, humanRNA-Binding ProteinsRNA, CircularRNA, MessengerCircular RNAsEMT pathwayHypoxiaIGF2BP3Metastasis

Identifiers

PMID38329630
OpenAlexW4391654444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.