Evidence map›Paper›PMID 38329608›Full record

ArticleJournal of endocrinological investigation2024

Role of IL33 in chronic inflammation and microvascular damage as a reflection of organ damage on a cohort of patients with acromegaly.

D Costa, C Pellicano, V Mercuri, E D'Ascanio, G Buglione, G Cicolani, U Basile, G Leodori, P Gargiulo, E Rosato

Abstract read
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In one paragraph

Article in Journal of endocrinological investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

D CostaDepartment of Experimental Medicine, Endocrinology-Pituitary Disease, "Sapienza" University of Rome, Rome, Italy.
C PellicanoDepartment of Traslational and Precision Medicine, Sapienza-University of Rome, Rome, Italy.
V MercuriDepartment of Experimental Medicine, Endocrinology-Pituitary Disease, "Sapienza" University of Rome, Rome, Italy.
E D'AscanioDepartment of Experimental Medicine, Endocrinology-Pituitary Disease, "Sapienza" University of Rome, Rome, Italy.
G BuglioneDepartment of Experimental Medicine, Endocrinology-Pituitary Disease, "Sapienza" University of Rome, Rome, Italy.
G CicolaniLaboratory of Seminology-Sperm Bank "Loredana Gandini", Department of Experimental Medicine, "Sapienza", University of Rome, Rome, Italy.
U BasileUOC of Clinical Pathology DEA II Level, Hospital Santa Maria Goretti of Latina-Italy, Latina, Italy.
G LeodoriDepartment of Traslational and Precision Medicine, Sapienza-University of Rome, Rome, Italy.
P GargiuloDepartment of Experimental Medicine, Endocrinology-Pituitary Disease, "Sapienza" University of Rome, Rome, Italy. patrizia.gargiulo@uniroma1.it.ORCID http://orcid.org/0000-0003-1216-2034
E RosatoDepartment of Traslational and Precision Medicine, Sapienza-University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAcromegaly is a rare chronic disease, caused by the over-secretion of growth hormone (GH), that creates a pro-inflammatory state, but the exact mechanisms by which GH or insulin-like growth factor 1 (IGF-1) act on inflammatory cells are not fully understood. Aim of the study was to evaluate Interleukin-33 (IL33) and the skin perfusion of hands in patients with acromegaly (AP) and healthy controls (HC).

methodsIL33 have been assessed in 40 AP and 40 HC. IL 33 was determined and skin perfusion of hands was assessed by laser speckle contrast analysis (LASCA) in both populations.

resultsIL33 was significantly higher in AP compared to HC [45.72 pg/ml (IQR 28.74-60.86) vs 14 pg/ml (IQR 6.5535); p < 0.05]. At LASCA, peripheral blood perfusion (PBP) was significantly lower in AP compared to HC [53.39 pU (IQR 40.94-65.44) vs 87 pU (IQR 80-98) p < 0.001]. The median values of ROI1, ROI2 and ROI3 were significantly lower in AP compared to HC [97.32 pU (IQR 50.89-121.69) vs 131 pU (IQR 108-135); p < 0.001], [58.68 pU (IQR 37.72-84.92) vs 83 pU (IQR 70-89), p < 0.05] and HC [52.16 (34.47-73.78) vs 85 (78-98), p < 0.001], respectively. The proximal-distal gradient (PDG) was observed in 18 of 40 (45%) AP.

conclusionSerum IL33 is higher in AP compared to HC; conversely a reduction of PBP of hands was present in AP compared to HC, probably due to endothelial dysfunction, strictly dependent on acromegaly and are not influenced by the choice of treatment.

Indexed as

AcromegalyInflammationInterleukin-33AdultBiomarkersCase-Control StudiesChronic DiseaseCohort StudiesFemaleHandHuman Growth HormoneHumansInsulin-Like Growth Factor ILaser Speckle Contrast ImagingMaleMicrovesselsBiomarkersHuman Growth HormoneIL33 protein, humanInsulin-Like Growth Factor IInterleukin-33AcromegalyChronic inflammationEndothelial disfunctionIGF-1Interleukin 33

Identifiers

PMID38329608
PMCPMC11266242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.