Evidence map›Paper›PMID 38329168›Full record

ArticleProteomics2024

An AI-generated proteome-scale dataset of predicted protein structures for the ctenophore Mnemiopsis leidyi.

R Travis Moreland, Suiyuan Zhang, Sofia N Barreira, Joseph F Ryan, Andreas D Baxevanis

Abstract read
In one paragraph

Article in Proteomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Rapid speciation in the holopelagic ctenophorebioRxiv : the preprint server for biology · 2024
    Article
  4. Morphological and dietary changes encoded in the genome ofNAR genomics and bioinformatics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

R Travis MorelandCenter for Genomics and Data Science Research, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0009-0007-1793-7413
Suiyuan ZhangCenter for Genomics and Data Science Research, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sofia N BarreiraCenter for Genomics and Data Science Research, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
Joseph F RyanWhitney Laboratory for Marine Bioscience, University of Florida, St. Augustine, Florida, USA.ORCID 0000-0001-5478-0522
Andreas D BaxevanisCenter for Genomics and Data Science Research, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-5370-0014

Funding

Phylogenomic Studies on the Evolution of Morphological ComplexityZIAHG000140 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAXEVANIS, ANDREAS · 2009 to 2025
$11.4M
Allen Distinguished Investigator Award, Paul G. Allen Frontiers Group, Paul G. Allen Family FoundationIntramural NIH HHS ZIA HG000140
6 · The paper itself

Abstract

This Dataset Brief describes the computational prediction of protein structures for the ctenophore Mnemiopsis leidyi. Here, we report the proteome-scale generation of 15,333 protein structure predictions using AlphaFold, as well as an updated implementation of publicly available search, manipulation, and visualization tools for these protein structure predictions through the Mnemiopsis Genome Project Portal (https://research.nhgri.nih.gov/mnemiopsis). The utility of these predictions is demonstrated by highlighting comparisons to experimentally determined structures for the light-sensitive protein mnemiopsin 1 and the ionotropic glutamate receptor (iGluR). The application of these novel protein structure prediction methods will serve to further position non-bilaterian species such as Mnemiopsis as powerful model systems for the study of early animal evolution and human health.

Indexed as

CtenophoraProteomeAnimalsComputational BiologyDatabases, ProteinProtein ConformationProteomicsProteomeevolutionary biologyprotein structure predictionstructural annotationvisualization

Identifiers

PMID38329168
PMCPMC11296891

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.