Evidence map›Paper›PMID 38329032›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes.

Laurens Winkelmeier, Jeremy J Heit, Gabriel Broocks, Julia Prüter, Christian Heitkamp, Maximilian Schell, Gregory W Albers, Maarten G Lansberg, Max Wintermark, André Kemmling and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Laurens WinkelmeierDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-9103-5983
Jeremy J HeitDepartment of Neuroradiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1055-8000
Gabriel BroocksDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-7575-9850
Julia PrüterDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christian HeitkampDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-8988-0918
Maximilian SchellDepartment of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gregory W AlbersDepartment of Neurology, Stanford University School of Medicine, Stanford, CA, USA.
Maarten G LansbergDepartment of Neurology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3545-6927
Max WintermarkDepartment of Neuroradiology, MD Anderson, Houston, Texas, USA.
André KemmlingDepartment of Neuroradiology, University Marburg, Marburg, Germany.
Christian Paul StrackeDepartment of Radiology, University Hospital Muenster, Muenster, Germany.
Adrien GuenegoDepartment of Neuroradiology, Erasme Medical Center, Brussels, Belgium.ORCID 0000-0001-7281-1652
Daniel PaechClinic for Neuroradiology, University Hospital Bonn, Bonn, Germany.
Jens FiehlerDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Tobias D FaizyDepartment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1631-2020

Funding

NSTN National Clinical Coordinating CenterU01NS086872 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Pooja Khatri · 2013 to 2026
$32.3M
Workshop to Identify Collaborative Project(s) for the NIH StrokeNet and the Japan NEtwork for Clinical Stroke Trials (NECST)U01NS087748 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Catherine R. Dillon, Jordan J. Elm · 2014 to 2026
$14.1M
The Vascular effects of Infection in Pediatric Stroke (VIPS II) StudyR01NS104094 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FULLERTON, HEATHER J · 2017 to 2022
$3.5M
NINDS NIH HHS R01 NS104094NINDS NIH HHS U01 NS086872NINDS NIH HHS U01 NS087748
6 · The paper itself

Abstract

Ischemic lesion net water uptake (NWU) represents a quantitative imaging biomarker for cerebral edema in acute ischemic stroke. Data on NWU for distinct occlusion locations remain scarce, but might help to improve the prognostic value of NWU. In this retrospective multicenter cohort study, we compared NWU between patients with proximal large vessel occlusion (pLVO; ICA or proximal M1) and distal large vessel occlusion (dLVO; distal M1 or M2). NWU was quantified by densitometric measurements of the early ischemic region. Arterial collateral status was assessed using the Maas scale. Regression analysis was used to investigate the relationship between occlusion location, NWU and ischemic lesion growth. A total of 685 patients met inclusion criteria. Early ischemic lesion NWU was higher in patients with pLVO compared with dLVO (7.7% vs 3.9%,

Indexed as

Ischemic StrokeAgedAged, 80 and overBrain EdemaBrain IschemiaCerebrovascular CirculationCollateral CirculationFemaleHumansMaleMiddle AgedRetrospective StudiesWaterWaterCerebral edemacerebrovascular circulationischemic strokeneuroimagingthrombectomy

Identifiers

PMID38329032
PMCPMC11342730

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.