Evidence map›Paper›PMID 38328935›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2024

Predicting Lipid-Rich Plaque Progression in Coronary Arteries Using Multimodal Imaging and Wall Shear Stress Signatures.

Giuseppe De Nisco, Eline M J Hartman, Elena Torta, Joost Daemen, Claudio Chiastra, Diego Gallo, Umberto Morbiducci, Jolanda J Wentzel

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Giuseppe De NiscoPolitoMed Laboratory, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy (G.D.N., E.T., C.C., D.G., U.M.).ORCID 0000-0003-1711-3047
Eline M J HartmanDepartment of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (E.M.J.H., J.D., J.J.W.).
Elena TortaPolitoMed Laboratory, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy (G.D.N., E.T., C.C., D.G., U.M.).ORCID 0000-0002-7071-2893
Joost DaemenDepartment of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (E.M.J.H., J.D., J.J.W.).ORCID 0000-0001-8628-1410
Claudio ChiastraPolitoMed Laboratory, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy (G.D.N., E.T., C.C., D.G., U.M.).ORCID 0000-0003-2070-6142
Diego GalloPolitoMed Laboratory, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy (G.D.N., E.T., C.C., D.G., U.M.).ORCID 0000-0002-7409-7111
Umberto MorbiducciPolitoMed Laboratory, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy (G.D.N., E.T., C.C., D.G., U.M.).ORCID 0000-0002-9854-1619
Jolanda J WentzelDepartment of Cardiology, Biomedical Engineering, Erasmus MC, Rotterdam, the Netherlands (E.M.J.H., J.D., J.J.W.).ORCID 0000-0001-9893-3404
Politecnico di Torino · ITErasmus University Rotterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPlaque composition and wall shear stress (WSS) magnitude act as well-established players in coronary plaque progression. However, WSS magnitude per se does not completely capture the mechanical stimulus to which the endothelium is subjected, since endothelial cells experience changes in the WSS spatiotemporal configuration on the luminal surface. This study explores WSS profile and lipid content signatures of plaque progression to identify novel biomarkers of coronary atherosclerosis.

methodsThirty-seven patients with acute coronary syndrome underwent coronary computed tomography angiography, near-infrared spectroscopy intravascular ultrasound, and optical coherence tomography of at least 1 nonculprit vessel at baseline and 1-year follow-up. Baseline coronary artery geometries were reconstructed from intravascular ultrasound and coronary computed tomography angiography and combined with flow information to perform computational fluid dynamics simulations to assess the time-averaged WSS magnitude (TAWSS) and the variability in the contraction/expansion action exerted by WSS on the endothelium, quantifiable in terms of topological shear variation index (TSVI). Plaque progression was measured as intravascular ultrasound-derived percentage plaque atheroma volume change at 1-year follow-up. Plaque composition information was extracted from near-infrared spectroscopy and optical coherence tomography.

resultsExposure to high TSVI and low TAWSS was associated with higher plaque progression (4.00±0.69% and 3.60±0.62%, respectively). Plaque composition acted synergistically with TSVI or TAWSS, resulting in the highest plaque progression (≥5.90%) at locations where lipid-rich plaque is exposed to high TSVI or low TAWSS.

conclusionsLuminal exposure to high TSVI, solely or combined with a lipid-rich plaque phenotype, is associated with enhanced plaque progression at 1-year follow-up. Where plaque progression occurred, low TAWSS was also observed. These findings suggest TSVI, in addition to low TAWSS, as a potential biomechanical predictor for plaque progression, showing promise for clinical translation to improve patient prognosis.

Indexed as

Coronary Artery DiseasePlaque, AtheroscleroticComputed Tomography AngiographyCoronary AngiographyCoronary VesselsEndothelial CellsHumansLipidsStress, MechanicalLipidscoronary artery diseasehemodynamicspatient-specific modelingplaque, atheroscleroticultrasonography

Identifiers

PMID38328935
PMCPMC10965126
OpenAlexW4391652000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.