Evidence map›Paper›PMID 38328671›Full record

ArticleFrontiers in cellular and infection microbiology2024

Rational design of antibodies and development of a novel method for (1-3)-β-D glucan detection as an alternative to Limulus amebocyte lysate assay.

Chunlong Liu, Lin Zhang, Jiaxing Zhang, Mengfan Wang, Shengping You, Rongxin Su, Wei Qi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. s_mmpbsa: A Lite and Cross-Platform MM-PBSA Program.Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chunlong Liu *Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Lin Zhang *Chemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Jiaxing ZhangChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Mengfan WangChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Shengping YouChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Rongxin SuChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Wei QiChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Tianjin University · CNCollaborative Innovation Center of Chemical Science and Engineering Tianjin · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With advances in medicine, increasing medical interventions have increased the risk of invasive fungal disease development. (1-3)-β-D glucan (BDG) is a common fungal biomarker in serological tests. However, the scarcity of Limulus resources for BDG detection poses a challenge. This study addresses the need for an alternative to Limulus amebocyte lysate by using BDG mutant antibody for chemiluminescence detection. The wild-type BDG antibody was obtained by immunizing rabbits. An optimal V52

Indexed as

beta-GlucansInvasive Fungal InfectionsAnimalsBase SequenceHorseshoe CrabsRabbitsROC CurveSensitivity and Specificitybeta-Glucans(1-3)-β-D glucanantibody rational designchemiluminescenceinvasive fungal infectionslimulusrapid detection

Identifiers

PMID38328671
PMCPMC10847287
OpenAlexW4391172598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.