Evidence map›Paper›PMID 38328401›Full record

ArticleCancer pathogenesis and therapy2023

Clinical characteristics and prognostic significance of immunoglobulin isotype switch in patients with multiple myeloma.

Minqiu Lu, Bin Chu, Yutong Wang, Lei Shi, Shan Gao, Lijuan Fang, Qiuqing Xiang, Xi Liu, Yuehua Ding, Yuan Chen and 4 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer pathogenesis and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Minqiu LuDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Bin ChuDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Yutong WangDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Lei ShiDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Shan GaoDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Lijuan FangDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Qiuqing XiangDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Xi LiuDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Yuehua DingDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Yuan ChenDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Xin ZhaoDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Mengzhen WangDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Kai SunDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.
Li BaoDepartment of Hematology, Beijing Jishuitan Hospital, The Fourth Medical College of Peking University, Beijing 100096, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin (Ig) isotype switching in multiple myeloma (MM) is a rare form of clonal evolution. The aim of this study was to investigate the clinical features and prognostic significance of Ig isotype switching by observing Ig transformation in patients with relapse. A retrospective analysis was performed on 506 patients with newly diagnosed MM who were treated at our hospital from February 2005 to February 2020. The patients who experienced relapse were divided into the following four groups according to Ig phenotype: original paraprotein, complete isotype switching, light chain escape (LCE),and non-secretory clinical relapse. For comparative purposes with the original paraprotein group, the last three groups were pooled as the transformation group. Among the 506 included patients, 376 (74.3%) relapsed. Among them, 13/376 (3.5%) patients exhibited Ig isotype switching, including 3 with complete isotype switching, 3 with LCE, and 7 with non-secretory clinical relapse. Eleven remained sensitive to therapy, exhibiting at least a partial response. Seven patients survived for at least 20 months after relapse. The median overall survival time of the LCE, clinical relapse, and complete isotype switching groups were 6, 20, and 76 months, respectively, after recurrence. The clinical manifestations and Ig phenotypes of MM recurrence were different from those at the initial diagnosis in the 13 patients exhibiting Ig isotype switching. These differences vividly conveyed the heterogeneity of the clonal populations and provides direct clinical evidence for MM clonal evolution.

Indexed as

Clinical characteristicsClonal evolutionImmunoglobulin isotype switchMultiple myelomaPrognosis

Identifiers

PMID38328401
PMCPMC10846323

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