Evidence map›Paper›PMID 38328367›Full record

ArticleVeterinary world2023

Efficient delivery of the immunodominant genes of African swine fever virus by adeno-associated virus serotype 2.

Rustam Ravilov, Antonina Galeeva, Gennadiy Frolov, Marina Efimova, Elena Zakirova, Albert Rizvanov, Almaz Hisamutdinov, Lenar Garipov, Danil Mingaleev

Abstract read
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In one paragraph

Article in Veterinary world, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rustam RavilovKazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
Antonina GaleevaKazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
Gennadiy FrolovKazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
Marina EfimovaKazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.
Elena ZakirovaLaboratory of Regenerative Veterinary Medicine, Kazan (Volga region) Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russia.
Albert RizvanovLaboratory of Regenerative Veterinary Medicine, Kazan (Volga region) Federal University, Institute of Fundamental Medicine and Biology, Kazan, Russia.
Almaz HisamutdinovMain Directorate of Veterinary Medicine, Ministry of the Tatarstan Republic, Kazan, Russia.
Lenar GaripovMinistry of Agriculture and Food of Tatarstan Republic, Kazan, Russia.
Danil MingaleevKazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Adeno-associated virus serotype 2 (AAV2) represents a promising basis for developing a virus-vector vaccine against African swine fever (ASF). This study aimed to create genetic constructs based on AAV2 to deliver the immunodominant genes of ASF virus (ASFV) and to evaluate their functionality Materials and Methods: Bioinformatics analysis methods were used to identify the immunodominant genes of ASFV. The target genes Results: The proposed AAV2 assembly protocol makes it possible to achieve a concentration of mature viral particles of at least 280 billion/mL of virus-containing material. The rAAV2 could effectively transduce host SPEV cells. The expression of both cistrons was detectable during the transduction of cells; therefore, the combined expression of immunogens in the cells of target animals should be possible using this method. Conclusion: This study demonstrated the potential of using genetic constructs based on AAV2 for the delivery of ASFV genes

Indexed as

adeno-associated virusAfrican swine fever virusgene deliveryvirally vectored vaccine

Identifiers

PMID38328367
PMCPMC10844788

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.