In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 6 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors at 1 institution in 1 country.
Benjamin KleinDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-3412-5536 Mehrnaz Gharaee-KermaniDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-2177-2427 Yiqing GaoDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.
Celine C BerthierDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0003-3539-1075 Svenja HenningDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-7895-6729 Shannon N LoftusDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0003-0608-5255 Kelsey E McNeelyDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-8255-6816 Amanda M VictoryDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-4948-5702 Feiyang MaDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-6260-0787 Jessica L TurnierDivision of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor.ORCID 0000-0002-1127-7879 J Michelle KahlenbergDivision of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor.ORCID 0000-0002-4006-8945 University of Michigan · US
Funding
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9MRESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANDRZEJ A. DLUGOSZ · 2019 to 2026
$6.6MCharacterization of Interferon Kappa as a Novel Target in Cutaneous LupusR01AR071384 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanne Michelle Kahlenberg · 2017 to 2026
$3.6MMitochondrial stress shapes host responses to bacterial infectionR01AI157384 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'RIORDAN, MARY · 2021 to 2025
$2.0MLinking Disease Mechanisms and Outcomes in Rheumatic DiseasesK24AR076975 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joanne Michelle Kahlenberg · 2020 to 2026
$910kHarnessing cutaneous transcriptional and myeloid cell signatures to understand treatment response in juvenile dermatomyositisK23AR080789 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Leigh Turnier · 2023 to 2026
$693kUnderstanding Transcriptional Connections between Cutaneous and Systemic LupusR03AR066337 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAHLENBERG, JOANNE MICHELLE · 2014 to 2016
$233kNIAID NIH HHS R01 AI157384NIAID NIH HHS T32 AI007413NIAMS NIH HHS K23 AR080789NIAMS NIH HHS K24 AR076975NIAMS NIH HHS P30 AR075043NIAMS NIH HHS R01 AR071384NIAMS NIH HHS R03 AR066337NIDDK NIH HHS P30 DK081943
6 · The paper itselfAbstract
Photosensitivity is observed in numerous autoimmune diseases and drives poor quality of life and disease flares. Elevated epidermal type I interferon (IFN) production primes for photosensitivity and enhanced inflammation, but the substrates that sustain and amplify this cycle remain undefined. Here, we show that IFN-induced Z-DNA binding protein 1 (ZBP1) stabilizes ultraviolet (UV)B-induced cytosolic Z-DNA derived from oxidized mitochondrial DNA. ZBP1 is significantly upregulated in the epidermis of adult and pediatric patients with autoimmune photosensitivity. Strikingly, lupus keratinocytes accumulate extensive cytosolic Z-DNA after UVB, and transfection of keratinocytes with Z-DNA results in stronger IFN production through cGAS-STING activation compared to B-DNA. ZBP1 knockdown abrogates UV-induced IFN responses, whereas overexpression results in a lupus-like phenotype with spontaneous Z-DNA accumulation and IFN production. Our results highlight Z-DNA and ZBP1 as critical mediators for UVB-induced inflammation and uncover how type I IFNs prime for cutaneous inflammation in photosensitivity.
Identifiers
PMID38328232
PMCPMC10849619
OpenAlexW4391269945
What OpenQuestion holds
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LicenceCC BY-NC-ND
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