Evidence map›Paper›PMID 38328205›Full record

ArticlebioRxiv : the preprint server for biology2024

Sensory Input, Sex, and Function Shape Hypothalamic Cell Type Development.

Harris S Kaplan, Brandon L Logeman, Kai Zhang, Celine Santiago, Noor Sohail, Serhiy Naumenko, Shannan J Ho Sui, David D Ginty, Bing Ren, Catherine Dulac

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Harris S KaplanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Brandon L LogemanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Kai ZhangDepartment of Cellular and Molecular Medicine, Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.ORCID 0000-0003-3454-7357
Celine SantiagoDepartment of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, 220 Longwood Ave, Boston, MA, 02115, USA.
Noor SohailDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
Serhiy NaumenkoDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
Shannan J Ho SuiDepartment of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
David D GintyDepartment of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, 220 Longwood Ave, Boston, MA, 02115, USA.
Bing RenDepartment of Cellular and Molecular Medicine, Center for Epigenomics, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.
Catherine DulacDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-5024-5418
Howard Hughes Medical Institute · USHarvard University · USUniversity of California San Diego · USWestlake University · CN

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Microcircuits underlying murine parental behaviorR01HD082131 · NICHD · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2015 to 2024
$3.5M
Molecular and Genetic Dissection of Brain Circuits Controlling FeverR01NS112399 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE · 2020 to 2024
$1.9M
Sex, Physiological State, and Genetic Background Dependent Molecular Characterization of CircuitsGoverning Parental BehaviorK99HD108801 · NICHD · HARVARD UNIVERSITY · PI LOGEMAN, BRANDON · 2023 to 2024
$246k
NHGRI NIH HHS UM1 HG011585NICHD NIH HHS K99 HD108801NICHD NIH HHS P50 HD105351NICHD NIH HHS R01 HD082131NIMH NIH HHS U19 MH114821NINDS NIH HHS R01 NS112399
6 · The paper itself

Abstract

Mammalian behavior and physiology undergo dramatic changes in early life. Young animals rely on conspecifics to meet their homeostatic needs, until weaning and puberty initiate nutritional independence and sex-specific social interactions, respectively. How neuronal populations regulating homeostatic functions and social behaviors develop and mature during these transitions remains unclear. We used paired transcriptomic and chromatin accessibility profiling to examine the developmental trajectories of neuronal populations in the hypothalamic preoptic region, where cell types with key roles in physiological and behavioral control have been identified

Identifiers

PMID38328205
PMCPMC10849564
OpenAlexW4391130586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.