Evidence map›Paper›PMID 38328168›Full record

ArticlebioRxiv : the preprint server for biology2024

Control of Munc13-1 Activity by Autoinhibitory Interactions Involving the Variable N-terminal Region.

Junjie Xu, Victoria Esser, Katarzyna Gołębiowska-Mendroch, Agnieszka A Bolembach, Josep Rizo

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Junjie XuDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Victoria EsserDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Katarzyna Gołębiowska-MendrochDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Agnieszka A BolembachDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.ORCID 0000-0003-1773-8311

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

Regulation of neurotransmitter release during presynaptic plasticity underlies varied forms of information processing in the brain. Munc13s play essential roles in release via their conserved C-terminal region, which contains a MUN domain involved SNARE complex assembly, and control multiple presynaptic plasticity processes. Munc13s also have a variable N-terminal region, which in Munc13-1 includes a calmodulin binding (CaMb) domain involved in short-term plasticity and a C

Indexed as

intramolecular interactionsNeurotransmitter releasepresynaptic plasticityprotein NMRsynaptic vesicle fusion

Identifiers

PMID38328168
PMCPMC10849727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.