Evidence map›Paper›PMID 38328122›Full record

ArticlebioRxiv : the preprint server for biology2024

Human vascular organoids with a mosaic

Siyu He, Yuefei Zhu, Shradha Chauhan, Daniel Naveed Tavakol, Jong Ha Lee, Rayna Batya-Leia Berris, Cong Xu, Jounghyun H Lee, Caleb Lee, Sarah Cai and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Siyu HeDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.ORCID 0000-0001-7187-3034
Yuefei ZhuDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Shradha ChauhanDepartment of Biological Sciences, Columbia University, New York, NY 10027, USA.
Daniel Naveed TavakolDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Jong Ha LeeDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Rayna Batya-Leia BerrisDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Cong XuDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Jounghyun H LeeDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Caleb LeeDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Sarah CaiDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Shannon McElroyDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Gordana Vunjak-NovakovicDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Raju TomerDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Elham AziziDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Bin XuDepartment of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA.
Yeh-Hsing LaoDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Columbia University · USColumbia University Irving Medical Center · USStevens Institute of Technology · USUniversity at Buffalo, State University of New York · US

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Integrated Microphysiological System of Cerebral Organoid and Blood Vessel for Disease Modeling and Neuropsychiatric Drug screeningUH3TR002151 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEONG, KAM W · 2020 to 2022
$3.6M
Nanoformulated CRISPR Ribonucleoproteins for Ultrasound-Facilitated Brain Gene EditingR21NS133635 · NINDS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LAO, YEH-HSING · 2023 to 2023
$442k
NCATS NIH HHS UH3 TR002151NCI NIH HHS P30 CA013696NINDS NIH HHS R21 NS133635
6 · The paper itself

Abstract

Vascular malformation, a key clinical phenotype of Proteus syndrome, lacks effective models for pathophysiological study and drug development due to limited patient sample access. To bridge this gap, we built a human vascular organoid model replicating Proteus syndrome's vasculature. Using CRISPR/Cas9 genome editing and gene overexpression, we created induced pluripotent stem cells (iPSCs) embodying the Proteus syndrome-specific AKT

Identifiers

PMID38328122
PMCPMC10849631
OpenAlexW4391286143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.