Evidence map›Paper›PMID 38328117›Full record

ArticlebioRxiv : the preprint server for biology2024

Mitochondrial uncoupler and retinoic acid synergistically induce differentiation and inhibit proliferation in neuroblastoma.

Haowen Jiang, Sarah Jane Tiche, Clifford JiaJun He, Mohamed Jedoui, Balint Forgo, Meng Zhao, Bo He, Yang Li, Albert M Li, Anh T Truong and 11 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 3 countries.

Haowen JiangDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4021-3820
Sarah Jane TicheDepartment of Surgery, Stanford University, Stanford, CA, USA.
Clifford JiaJun HeDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Mohamed JedouiDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Balint ForgoDepartment of Pathology, Stanford University, Stanford, CA, USA.
Meng ZhaoDepartment of Pathology, Stanford University, Stanford, CA, USA.
Bo HeDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1471-9772
Yang LiDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Albert M LiDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Anh T TruongAgilent Technologies, Inc., Santa Clara, CA, USA.
Jestine HoAgilent Technologies, Inc., Santa Clara, CA, USA.
Cathyrin SimmermakerAgilent Technologies, Inc., Santa Clara, CA, USA.
Yanan YangAgilent Technologies, Inc., Santa Clara, CA, USA.
Meng-Ning ZhouDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.
Zhen HuOlivia Consulting Service, Redwood City, CA, USA.
Daniel J CuthbertsonAgilent Technologies, Inc., Santa Clara, CA, USA.
Katrin J SvenssonDepartment of Pathology, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5376-5128
Florette K HazardDepartment of Pathology, Stanford University, Stanford, CA, USA.
Hiroyuki ShimadaDepartment of Pathology, Stanford University, Stanford, CA, USA.
Bill ChiuDepartment of Surgery, Stanford University, Stanford, CA, USA.
Jiangbin YeDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1117-4869
Stanford University · USAgilent Technologies (United States) · USCardiovascular Institute of the South · USRED Consulting (Norway) · NO

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Mechanisms controlling fructose uptake and utilizationR01DK125260 · NIDDK · STANFORD UNIVERSITY · PI Katrin Jennifer Svensson · 2020 to 2026
$3.5M
Investigating Isthmin as an adipose-to-muscle messenger that promotes muscle protein synthesisK99AR081618 · NIAMS · STANFORD UNIVERSITY · PI ZHAO, MENG · 2023 to 2024
$182k
NIAMS NIH HHS K99 AR081618NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK125260
6 · The paper itself

Abstract

Neuroblastoma is a leading cause of death in childhood cancer cases. Unlike adult malignancies, which typically develop from aged cells through accumulated damage and mutagenesis, neuroblastoma originates from neural crest cells with disrupted differentiation. This distinct feature provides novel therapeutic opportunities beyond conventional cytotoxic methods. Previously, we reported that the mitochondrial uncoupler NEN (niclosamide ethanolamine) activated mitochondria respiration to reprogram the epigenome, promoting neuronal differentiation. In the current study, we further combine NEN with retinoic acid (RA) to promote neural differentiation both

Identifiers

PMID38328117
PMCPMC10849550
OpenAlexW4391215696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.