Evidence map›Paper›PMID 38328108›Full record

ArticlebioRxiv : the preprint server for biology2024

Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory.

Aliza A Le, Julie C Lauterborn, Yousheng Jia, Conor D Cox, Gary Lynch, Christine M Gall

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aliza A LeDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0002-9155-0838
Julie C LauterbornDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0002-8444-6151
Yousheng JiaDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0001-7353-1791
Conor D CoxDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0003-0264-9842
Gary LynchDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0002-3520-8544
Christine M GallDepartments of Anatomy and Neurobiology, University of California; Irvine, 92697, USA.ORCID 0000-0002-7727-796X
University of California, Irvine · US

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2018 to 2026
$18.2M
Loss and rescue of endocannabinoid-dependent LTP and memory in Fragile-X model miceR01HD089491 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GALL, CHRISTINE M, LYNCH, GARY S · 2016 to 2020
$2.2M
Training Program in Learning and MemoryT32MH119049 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BRUCE L MCNAUGHTON, Manuella Yassa · 2019 to 2026
$1.4M
NICHD NIH HHS R01 HD089491NIDA NIH HHS P50 DA044118NIMH NIH HHS T32 MH119049
6 · The paper itself

Abstract

Men generally outperform women on encoding spatial components of episodic memory whereas the reverse holds for semantic elements. Here we show that female mice outperform males on tests for non-spatial aspects of episodic memory ("what", "when"), suggesting that the human findings are influenced by neurobiological factors common to mammals. Analysis of hippocampal synaptic plasticity mechanisms and encoding revealed unprecedented, sex-specific contributions of non-classical metabotropic NMDA receptor (NMDAR) functions. While both sexes used non-ionic NMDAR signaling to trigger actin polymerization needed to consolidate long-term potentiation (LTP), NMDAR GluN2B subunit antagonism blocked these effects in males only and had the corresponding sex-specific effect on episodic memory. Conversely, blocking estrogen receptor alpha eliminated metabotropic stabilization of LTP and episodic memory in females only. The results show that sex differences in metabotropic signaling critical for enduring synaptic plasticity in hippocampus have significant consequences for encoding episodic memories.

Identifiers

PMID38328108
PMCPMC10849651
OpenAlexW4391278556

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.