Evidence map›Paper›PMID 38328085›Full record

ArticlebioRxiv : the preprint server for biology2024

Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.

Destiny E Berisha, Batool Rizvi, Miranda G Chappel-Farley, Nicholas Tustison, Lisa Taylor, Abhishek Dave, Negin S Sattari, Ivy Y Chen, Kitty K Lui, John C Janecek and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Destiny E BerishaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.ORCID 0000-0002-9554-9666
Batool RizviDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Miranda G Chappel-FarleyDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Nicholas TustisonCenter for the Neurobiology of Learning and Memory, University of California Irvine, Irvine CA, 92697, USA.
Lisa TaylorDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Abhishek DaveDepartment of Cognitive Sciences, University of California Irvine, Irvine CA, 92697, USA.
Negin S SattariDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Ivy Y ChenDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Kitty K LuiSan Diego State University/University of California San Diego, Joint Doctoral Program in Clinical Psychology, San Diego, CA, 92093, USA.
John C JanecekDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
David KeatorDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Ariel B NeikrugDepartment of Psychiatry and Human Behavior, University of California Irvine, Irvine CA, 92697, USA.
Ruth M BencaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Michael A YassaDepartment of Neurobiology and Behavior, University of California Irvine, Irvine CA, 92697, USA.
Bryce A ManderCenter for the Neurobiology of Learning and Memory, University of California Irvine, Irvine CA, 92697, USA.

Funding

Neuroimaging biomarkers for cognitive decline in elderly with amyloid pathologyR01AG053555 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Michael A Yassa · 2017 to 2026
$17.0M
Relationships between local and global mechanisms of sleep apnea, Alzheimer's disease biomarkers, and memory impairment in cognitively asymptomatic older adultsK01AG068353 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MANDER, BRYCE A. · 2020 to 2024
$636k
Circuit-specific tau burden and mechanisms of sleep-dependent memory processing in older adults at risk for Alzheimer’s diseaseR21AG079552 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MANDER, BRYCE A., YASSA, MICHAEL A · 2022 to 2022
$432k
Neurobiological mechanisms of sleep and exercise effects on memory in older adults at risk for Alzheimer's diseaseF31AG074703 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHAPPEL-FARLEY, MIRANDA · 2021 to 2023
$111k
NIA NIH HHS F31 AG074703NIA NIH HHS K01 AG068353NIA NIH HHS R01 AG053555NIA NIH HHS R21 AG079552
6 · The paper itself

Abstract

Obstructive sleep apnea (OSA) is common in older adults and is associated with medial temporal lobe (MTL) degeneration and memory decline in aging and Alzheimer's disease (AD). However, the underlying mechanisms linking OSA to MTL degeneration and impaired memory remains unclear. By combining magnetic resonance imaging (MRI) assessments of cerebrovascular pathology and MTL structure with clinical polysomnography and assessment of overnight emotional memory retention in older adults at risk for AD, cerebrovascular pathology in fronto-parietal brain regions was shown to statistically mediate the relationship between OSA-related hypoxemia, particularly during rapid eye movement (REM) sleep, and entorhinal cortical thickness. Reduced entorhinal cortical thickness was, in turn, associated with impaired overnight retention in mnemonic discrimination ability across emotional valences for high similarity lures. These findings identify cerebrovascular pathology as a contributing mechanism linking hypoxemia to MTL degeneration and impaired sleep-dependent memory in older adults.

Identifiers

PMID38328085
PMCPMC10849660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.