Evidence map›Paper›PMID 38328083›Full record

ArticlebioRxiv : the preprint server for biology2024

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis.

Blessy Paul, Holly Merta, Rupali Ugrankar-Banerjee, Monica Hensley, Son Tran, Goncalo Dias do Vale, Jeffrey G McDonald, Steven A Farber, W Mike Henne

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Blessy PaulDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-5118-1919
Holly MertaDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-4962-3658
Rupali Ugrankar-BanerjeeDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-3370-7470
Monica HensleyDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.
Son TranDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0009-0006-8814-1343
Goncalo Dias do ValeDepartment of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1104-0289
Jeffrey G McDonaldDepartment of Molecular Genetics, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1570-4142
Steven A FarberDepartment of Biology, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-8037-7312
W Mike HenneDepartment of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2135-2799
Southwestern Medical Center · USJohns Hopkins University · US

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Identifying genes required for digestive physiology and lipid metabolismR01DK093399 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, John F Rawls · 2013 to 2026
$7.6M
Spatial determinants in lipid metabolic organization at the sub-organelle levelR35GM119768 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Mike Henne · 2016 to 2026
$4.1M
In vivo HTS assay for novel modulators of Apolipoprotien BR01DK116079 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FARBER, STEVEN A · 2018 to 2022
$3.2M
Mechanisms of lipid droplet organization and functional diversificationR01DK126887 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Mike Henne, sarah huen · 2021 to 2026
$2.4M
NCI NIH HHS P30 CA142543NIDDK NIH HHS R01 DK093399NIDDK NIH HHS R01 DK116079NIDDK NIH HHS R01 DK126887NIGMS NIH HHS R35 GM119768
6 · The paper itself

Abstract

Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality control. Using multi-organismal profiling featuring

Identifiers

PMID38328083
PMCPMC10849633
OpenAlexW4391291441

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.