Evidence map›Paper›PMID 38328070›Full record

ArticlebioRxiv : the preprint server for biology2024

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation.

Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Christopher Chin SangDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Gaelen MooreDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Maria TereshchenkoDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Michael L NosellaDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Hongshan ZhangDepartment of Molecular Biosciences, University of Texas at Austin, TX, USA.
T Reid AldersonDivision of Molecular Biology and Biochemistry, Medizinische Universität Graz, Graz, 8010, Austria.
Morgan DasovichDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Anthony LeungDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Ilya J FinkelsteinDepartment of Molecular Biosciences, University of Texas at Austin, TX, USA.
Julie D Forman-KayDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
Hyun O LeeDepartment of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.
University of Toronto · CABloomberg (United States) · USThe University of Texas at Austin · USUniversity of Graz · AT

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
NCI NIH HHS P01 CA092584
6 · The paper itself

Abstract

Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity - poly(ADP-ribosyl)ation (PARylation). The enrichment of DNA repair proteins at sites of DNA damage has been described as the formation of a biomolecular condensate. However, it is not understood how PARP1 and PARylation contribute to the formation and organization of DNA repair condensates. Using recombinant human PARP1

Indexed as

ADP-ribosylationbiomolecular condensatesDNA repairPARP1phase separationpost-translational modifications (PTMs)single-strand break repair (SSBR)

Identifiers

PMID38328070
PMCPMC10849519
OpenAlexW4391104521

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.