Evidence map›Paper›PMID 38328063›Full record

ArticlebioRxiv : the preprint server for biology2023

Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial forebrain domains.

E L Bearer, C S Medina, T W Uselman, R E Jacobs

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

E L BearerDepartment of Pathology, Univ. of New Mexico Health Sciences Center, Albuquerque, NM.ORCID 0000-0002-8390-8529
C S MedinaDepartment of Pathology, Univ. of New Mexico Health Sciences Center, Albuquerque, NM.
T W UselmanDepartment of Pathology, Univ. of New Mexico Health Sciences Center, Albuquerque, NM.ORCID 0000-0002-3856-5248
R E JacobsZilkha Neurogenetic Institute, USC Keck School of Medicine, Los Angeles, CA.ORCID 0000-0002-1382-8486
University of New Mexico · USCalifornia Institute of Technology · US

Funding

Live imaging of brain circuitry in mouse models of PTSDR01MH096093 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BEARER, ELAINE L · 2012 to 2016
$2.8M
In Vivo Detection of Neuronal ActivityR01DA018184 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI JACOBS, RUSSELL E · 2006 to 2010
$1.8M
NIDA NIH HHS R01 DA018184NIMH NIH HHS R01 MH096093
6 · The paper itself

Abstract

Neurons project long axons that contact other distant neurons. Projections can be mapped by hijacking endogenous membrane trafficking machinery by introducing tracers. To witness functional connections in living animals, we developed a tracer detectible by magnetic resonance imaging (MRI), Mn(II). Mn(II) relies on kinesin-1 and amyloid-precursor protein to travel out axons. Within 24h, projection fields of cortical neurons can be mapped brain-wide with this technology. MnCl

Indexed as

amygdalaanterior cingulate area (ACA) and infralimbic-prelimbic cortex (IL/PL)Axonal transportcomputational image analysishypthalamusmanganese-enhanced magnetic resonance imaging (MEMRI)medial prefrontal cortex (mPFC)statistical parametric mapping (SPM)

Identifiers

PMID38328063
PMCPMC10849663
OpenAlexW4386616089

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.