Evidence map›Paper›PMID 38328026›Full record

ArticleCerebral circulation - cognition and behavior2024

Pulse pressure and APOE ε4 dose interact to affect cerebral blood flow in older adults without dementia.

Lauren Edwards, Kelsey R Thomas, Alexandra J Weigand, Emily C Edmonds, Alexandra L Clark, Einat K Brenner, Sarah J Banks, Paul E Gilbert, Daniel A Nation, Lisa Delano-Wood and 2 more

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In one paragraph

Article in Cerebral circulation - cognition and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lauren EdwardsSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Kelsey R ThomasResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.
Alexandra J WeigandSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Emily C EdmondsBanner Alzheimer's Institute, Tucson, AZ, USA.
Alexandra L ClarkDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Einat K BrennerDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Sarah J BanksDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Paul E GilbertSan Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.
Daniel A NationDepartment of Psychology, University of California Irvine, Irvine, CA, USA.
Lisa Delano-WoodDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Mark W BondiDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
Katherine J BangenResearch Service, VA San Diego Healthcare System, San Diego, CA, USA.

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark W Bondi · 2019 to 2026
$34.9M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Intracranial arterial compliance, cerebral blood flow, and dementia risk in older adults with type 2 diabetesR01AG063782 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGEN, KATHERINE · 2020 to 2024
$3.7M
NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG063782
6 · The paper itself

Abstract

This study assessed whether the effect of vascular risk on cerebral blood flow (CBF) varies by gene dose of apolipoprotein (APOE) ε4 alleles. 144 older adults without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent arterial spin labeling and T1-weighted MRI, APOE genotyping, fluorodeoxyglucose positron emission tomography (FDG-PET), lumbar puncture, and blood pressure (BP) assessment. Vascular risk was assessed using pulse pressure (systolic BP - diastolic BP). CBF was examined in six AD-vulnerable regions: entorhinal cortex, hippocampus, inferior temporal cortex, inferior parietal cortex, rostral middle frontal gyrus, and medial orbitofrontal cortex. Linear regressions tested the interaction between APOE ε4 dose and pulse pressure on CBF in each region, adjusting for age, sex, cognitive classification, antihypertensive medication use, FDG-PET, reference CBF region, and AD biomarker positivity. There was a significant interaction between pulse pressure and APOE ɛ4 dose on CBF in the entorhinal cortex, hippocampus, and inferior parietal cortex, such that higher pulse pressure was associated with lower CBF only among ε4 homozygous participants. These findings demonstrate that the association between pulse pressure and regional CBF differs by APOE ε4 dose, suggesting that targeting modifiable vascular risk factors may be particularly important for those genetically at risk for AD.

Indexed as

Alzheimer's diseaseApolipoprotein EArterial spin labelingCerebral blood flowPulse pressure

Identifiers

PMID38328026
PMCPMC10847851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.