Evidence map›Paper›PMID 38327958›Full record

ArticleCureus2024

Herba Epimedii and Increased Opioid Cravings While on Buprenorphine: A Case Report.

Heather Burke, Bernard A Sarmiento, Matthew Gunther, Richard Czuma, Cory Klippel, Shixie Jiang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heather BurkeDepartment of Psychiatry and Human Behavior, Brown University, Providence, USA.
Bernard A SarmientoCollege of Medicine, University of Central Florida, Orlando, USA.
Matthew GuntherDepartment of Psychiatry, Stanford University School of Medicine, Palo Alto, USA.
Richard CzumaDepartment of Psychiatry, Edward Hines, Jr. Veterans Administration Hospital, Hines, USA.
Cory KlippelMental Health and Behavioral Sciences, James A. Haley Veterans' Hospital, Tampa, USA.
Shixie JiangDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herba Epimedii, commonly known as yin yang huo, inyokaku, and horny goat weed, is a traditional Chinese herbal medicine utilized for treating osteoporosis and enhancing libido. Studies conducted in vitro have demonstrated that Herba Epimedii interacts with the enzyme cytochrome P450 3A4 (CYP3A4). This interaction poses a potential risk for drug-drug interactions, particularly with medications metabolized by CYP3A4, such as buprenorphine. This paper presents a case of a patient experiencing exacerbated opioid cravings following the initiation of Herba Epimedii. This is the first reported case supporting this interaction, emphasizing the necessity of screening for alternative medicines in patients undergoing medication-assisted treatments for opioid use disorder.

Indexed as

alternative medicinebuprenorphinecyp 3a4drug-drug interactionsherba epimediiherbal medicine usemedication-assisted treatmentopioid use disorder (oud)substance use screening

Identifiers

PMID38327958
PMCPMC10849866

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.