SynthesisFrontiers in endocrinology2023
Complex relationship between growth hormone and sleep in children: insights, discrepancies, and implications.
Synthesis in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Sleep disturbances in anorexia nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025Pooled it
- The association between sleep consolidation and growth and development in early childhood: A systematic review.Health promotion perspectives · 2024Pooled it
- Morning vs. evening growth hormone injections and their impact on sleep-wake patterns and daytime alertness.Frontiers in endocrinology · 2025Trial
- Energy Drink Use and Adolescent Sleep Debt: Implications for Obesity, Cognition, and Physical Activity.Nutrients · 2026Review
- Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study.Children (Basel, Switzerland) · 2026Article
- Exploring Factors Associated with Physical Exercise Participation Among Chinese Adults Based on Explainable Machine Learning Methods.Behavioral sciences (Basel, Switzerland) · 2026Article
- A longitudinal assessment of sleep architecture in children and adolescents with craniopharyngioma.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Long-acting growth hormone therapy in paediatric growth hormone deficiency: reduced treatment burden and unproven motivation-related neuroendocrine effects.Frontiers in endocrinology · 2026Review
- Article
- Effect of a 90-Minute Nap at Different Times of the Day on Physical Performance, Psycho-Cognitive Responses, and Perceived Recovery in Trained Youth Male Athletes.Sports (Basel, Switzerland) · 2025Article
- Impact of COVID-19 infection on the sleep of infants and toddlers.BMC pediatrics · 2025Article
- Long-term sleep disturbance following burn injury: Insights from the Burn Model System.Burns : journal of the International Society for Burn Injuries · 2025Article
- Addressing Stunting in Children Under Five: Insights and Opportunities from Nepal, Bangladesh, and Vietnam-A Review of Literature.Children (Basel, Switzerland) · 2025Review
- Article
- Spinal sagittal and coronal morphology characteristics in children with short stature.Quantitative imaging in medicine and surgery · 2025Article
- Higher prevalence of short stature and excess weight in children with sleep disorders.Frontiers in endocrinology · 2025Article
- A biopsychosocial approach to sleep health during puberty: Individual and contextual aspects and the role of gender differences. A narrative review.Cogent mental health · 2025Review
- SDIMMMER: A Proposed Clinical Approach to Optimize Cellular Physiology in Regenerative Medicine.Life (Basel, Switzerland) · 2024Article
- Analysis and prediction of protein-energy malnutrition in children aged 8-10 years.American journal of translational research · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth hormone (GH) is crucial to growth and development. GH secretion is regulated by a complex feedback system involving the pituitary gland, hypothalamus, and other organs, and predominantly occurs during deep sleep. Isolated and idiopathic growth hormone deficiency (GHD) is a condition characterized by GHD without any other signs or symptoms associated with a specific syndrome or disease. The aim of this narrative review was to evaluate the relationship between GH and sleep in children using published data. Various databases (Medline/PubMed, Scopus, and Web of Science) were systematically searched for relevant English language articles published up to April 2023. Search strategies included the terms 'children/pediatric', 'growth hormone', 'growth hormone deficiency' and 'sleep'. Data were extracted by two independent reviewers; 185 papers were identified of which 58 were duplicates and 118 were excluded (unrelated n=83, syndromic/genetic GHD n=17, non-English n=13, abstract n=1, case report n=1). Overall, nine studies (six clinical studies, two case series, and one survey) were included. GHD appears to have an adverse effect on sleep in children, and GH therapy has only been shown to have a beneficial effect on sleep parameters in some individuals. Notably, identified data were limited, old/poor quality, and heterogenous/inconsistent. Further research of GHD in pediatric populations is necessary to improve the understanding of GHD impact on sleep and its underlying mechanisms, and to determine the specific impacts of GH therapy on sleep in children.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.