Evidence map›Paper›PMID 38327833›Full record

ArticleCancer pathogenesis and therapy2023

Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy.

Liyu Zhu, Lin Wang, Zhidong Gao, Yujian Zeng, Kaixiong Tao, Quan Wang, Xinming Li, Huanhu Zhang, Zhanlong Shen, Jing Zhou and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer pathogenesis and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Liyu ZhuDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Lin WangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zhidong GaoDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Yujian ZengYunnan Institute of Digestive Disease, Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
Kaixiong TaoDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China.
Quan WangDepartment of Gastrointestinal and Anal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Xinming LiDepartment of Gastrointestinal and Anal Surgery, Huangshi Central Hospital, Huangshi, Hubei 435000, China.
Huanhu ZhangDepartment of Gastrointestinal Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, China.
Zhanlong ShenDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Jing ZhouDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Kai ShenDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Yingjiang YeDepartment of Gastroenterological Surgery, Peking University People's Hospital, Beijing 100044, China.
Aiwen WuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The number of lymph nodes examined (LNe) is often insufficient in patients with rectal cancer (RC) treated with neoadjuvant therapy; however, its prognostic value remains controversial. Thus, we retrospectively explored whether LNe had an influence on staging and prognosis and investigated whether there was a cut-off value for better prognosis in patients with RC treated with neoadjuvant therapy. Methods: Data were collected from seven prospective hospital databases in China from July 2002 to May 2018. Binary logistic regression models were used to predict lymph node metastasis. The cut-off value for LNe was determined using X-tile 3.6.1. Survival outcomes and risk factors were analyzed using the log-rank test and Cox regression model. Results: A total of 482 patients were included, of whom 459 had complete overall survival (OS) information. Using the percentile method, the total number of lymph nodes examined (TLNe) was 14-16 (40th-60th percentile), and the proportion of patients with lymph node metastasis reached a maximum of 48.1%. Cox multivariate analysis showed that the odds ratio (OR) remained the highest when TLNe was 14-16 (OR = 3.379, Conclusion: The TLNe and NLNe influenced the staging accuracy and demonstrated prognostic value in patients with RC treated with neoadjuvant therapy.

Indexed as

Lymph nodes examinedNeoadjuvant therapyPrognosisRectal cancerStaging accuracy

Identifiers

PMID38327833
PMCPMC10846314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.