Evidence map›Paper›PMID 38327824›Full record

ReviewBioactive materials2024

Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications.

Rongqiu Mu, Danzhu Zhu, Sama Abdulmalik, Suranji Wijekoon, Gang Wei, Sangamesh G Kumbar

Abstract readReview
In one paragraph

Review in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Self-Assembly of Peptides and Biomolecular Systems Into Functional Nanomaterials.Journal of peptide science : an official publication of the European Peptide Society · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Self-Assembling Short Peptide Carriers for Gene Delivery.International journal of molecular sciences · 2026
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rongqiu MuCollege of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, China.
Danzhu ZhuCollege of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, China.
Sama AbdulmalikDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, 06030, USA.
Suranji WijekoonDepartment of Orthopaedic Surgery, University of Connecticut Health, Farmington, 06030, USA.
Gang WeiCollege of Chemistry and Chemical Engineering, Qingdao University, 266071, Qingdao, China.
Sangamesh G KumbarDepartment of Biomedical Engineering & Department of Materials Science and Engineering, University of Connecticut, Storrs, 06269, USA.

Funding

Targeting PHLPP to treat interval disc degeneration using surgical and drug delivery methodsR01AR078908 · NIAMS · EMORY UNIVERSITY · PI Svenja Illien-Junger · 2022 to 2026
$1.9M
Biodegradable Matrices for Bone HealingR01EB020640 · NIBIB · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA, YU, XIAOJUN · 2017 to 2020
$1.6M
Polysaccharide putty formulations for tissue regenerationR01EB034202 · NIBIB · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2023 to 2026
$1.5M
Biodegradable Matrices with Structural and Physical Cues for Interface EngineeringR01EB030060 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI NUKAVARAPU, SYAM · 2020 to 2024
$1.4M
Supplement to Support the Acquisition of a High-Precision 3D PrinterR01NS134604 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Sangamesh Gurappa Kumbar · 2024 to 2026
$1.3M
Engineered Matrices with Electrical and Chemical Stimulation for Peripheral Nerve RepairR56NS122753 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KUMBAR, SANGAMESH GURAPPA · 2022 to 2022
$410k
NIAMS NIH HHS R01 AR078908NIBIB NIH HHS R01 EB020640NIBIB NIH HHS R01 EB030060NIBIB NIH HHS R01 EB034202NINDS NIH HHS R01 NS134604NINDS NIH HHS R56 NS122753
6 · The paper itself

Abstract

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering and biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances their stimuli-responsive functions, promoting function-specific applications that induced by both internal and external stimulations. In this review, we demonstrate recent advance in the peptide molecular design, self-assembly, functional tailoring, and biomedical applications of peptide-based nanomaterials. The strategies on the design and synthesis of single, dual, and multiple stimuli-responsive peptide-based nanomaterials with various dimensions are analyzed, and the functional regulation of peptide nanomaterials with active components such as metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, and others are discussed. In addition, the designed peptide-based nanomaterials with temperature-, pH-, ion-, light-, enzyme-, and ROS-responsive abilities for drug delivery, bioimaging, cancer therapy, gene therapy, antibacterial, as well as wound healing and dressing applications are presented and discussed. This comprehensive review provides detailed methodologies and advanced techniques on the synthesis of peptide nanomaterials from molecular biology, materials science, and nanotechnology, which will guide and inspire the molecular level design of peptides with specific and multiple functions for function-specific applications.

Indexed as

Biomedical applicationsFunctional modulationMolecular designPeptide assembliesStimuli-responsive nanomaterials

Identifiers

PMID38327824
PMCPMC10847779

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.