Evidence map›Paper›PMID 38327783›Full record

ArticleiScience2024

Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.

Youngchang Kim, Natalia Maltseva, Christine Tesar, Robert Jedrzejczak, Michael Endres, Heng Ma, Haley L Dugan, Christopher T Stamper, Changsoo Chang, Lei Li and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Youngchang KimCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Natalia MaltsevaCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Christine TesarCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Robert JedrzejczakCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Michael EndresCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Heng MaData Science and Learning Division, Argonne National Laboratory, Lemont, IL 60439, USA.
Haley L DuganDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Christopher T StamperDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Changsoo ChangCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Lei LiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Siriruk ChangrobDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Nai-Ying ZhengDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Min HuangDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60367, USA.
Arvind RamanathanData Science and Learning Division, Argonne National Laboratory, Lemont, IL 60439, USA.
Patrick WilsonGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10021, USA.
Karolina MichalskaCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Andrzej JoachimiakCenter for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, IL 60367, USA.
Argonne National Laboratory · USUniversity of Chicago · USCornell University · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
TO PROVIDE SCIENTIFIC SUPPORT TO THE CENTERS FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES.75N93022C00035 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SATCHELL, KARLA · 2022 to 2025
$20.7M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
PanCorVac (Center for Pan-Coronavirus Vaccine Development)P01AI165077 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KAWAOKA, YOSHIHIRO · 2021 to 2023
$11.6M
NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93022C00035NIAID NIH HHS HHSN272201700060CNIAID NIH HHS P01 AI165077NIAID NIH HHS T32 AI007090
6 · The paper itself

Abstract

Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting genomic RNA. The protein shares sequence, structure, and architecture with nucleocapsid proteins from betacoronaviruses. The N-terminal domain (NP

Indexed as

BiochemistryImmunologyStructural biology

Identifiers

PMID38327783
PMCPMC10847736
OpenAlexW4391065228

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.