Evidence map›Paper›PMID 38327766›Full record

ArticleFrontiers in immunology2023

Nucleotide alterations in the HLA-C class I gene can cause aberrant splicing and marked changes in RNA levels in a polymorphic context-dependent manner.

Akiko Mizutani, Shingo Suzuki, Atsuko Shigenari, Tadayuki Sato, Masafumi Tanaka, Jerzy K Kulski, Takashi Shiina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Akiko MizutaniDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Shingo SuzukiDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Atsuko ShigenariDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Tadayuki SatoDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Masafumi TanakaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Jerzy K KulskiDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Takashi ShiinaDepartment of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Tokai University · JPTeikyo Heisei University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphisms of HLA genes, which play a crucial role in presenting peptides with diverse sequences in their peptide-binding pockets, are also thought to affect HLA gene expression, as many studies have reported associations between HLA gene polymorphisms and their expression levels. In this study, we devised an ectopic expression assay for the HLA class I genes in the context of the entire gene, and used the assay to show that the

Indexed as

HLA-C AntigensNucleotidesAlternative SplicingRNA Splice SitesRNA SplicingHLA-C AntigensNucleotidesRNA Splice Sitesalternative splicingectopic expression assayHLA Class I geneshuman leukocyte antigenpolymorphismsRNA levels

Identifiers

PMID38327766
PMCPMC10847315
OpenAlexW4391172675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.