ArticleFrontiers in immunology2023
Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.
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Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 29 citations in OpenAlex.
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- A new paradigm: 46 structural cell types function as environment-supporting innate immune cells, with endothelial and vascular smooth muscle cells as key prototypes.iNew medicine · 2026Article
- Novel Organelle-Based Intracellular Immunity with Mechanistic and Therapeutic Implications.Barrier immunity · 2026Article
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- Trained Immunity-Like Memory in Vascular Structural Cells: Metabolic-Epigenetic Reprogramming as a Driving Mechanism of Atherosclerosis and Residual Cardiovascular Risk.Journal of inflammation research · 2026Review
- Reduced R-loop abundance at proinflammatory loci: a shared epigenetic mechanism in inflammatory and metabolic diseases.Frontiers in cardiovascular medicine · 2026Article
- Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation.Frontiers in medicine · 2026Article
- Prognostic Role of Cuproptosis-Related Gene after Intracerebral Hemorrhage in Mice.Cellular and molecular neurobiology · 2025Article
- Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model.Journal of Alzheimer's disease : JAD · 2025Article
- Accelerating and protective effects toward cancer growth in cGAS and FcgRIIb deficient mice, respectively, an impact of macrophage polarization.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- SET7 lysine methyltransferase mediates the up-regulation of NADPH oxidase expression, oxidative stress, and NLRP3 inflammasome priming in atherosclerosis.Journal of translational medicine · 2025Article
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- Anthocyanins from a new hybrid sweet potato peel cultivated in Northern Thailand mitigate LPS-induced inflammation and RANKL-induced osteoporosis by regulating ROS-mediated pathways.Inflammopharmacology · 2025Article
- Organelle stresses and energetic metabolisms promote endothelial-to-mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer's disease.Frontiers in molecular neuroscience · 2025Article
- Features of Gene Regulation in Violation of the Inflammatory Response of Monocyte-like Cells Bearing Mitochondrial Mutations Associated with Atherosclerosis.Current medicinal chemistry · 2025Article
- Olfactory Receptors and Aortic Aneurysm: Review of Disease Pathways.Journal of clinical medicine · 2024Review
- Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4International journal of drug discovery and pharmacology · 2024Article
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Authors and funding
19 authors at 4 institutions in 1 country.
Qiaoxi YangLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Fatma SaaoudLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yifan LuLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yujiang PuCollege of Letters & Science, University of Wisconsin-Madison, Madison, WI, United States.
Keman XuLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ying ShaoLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaohua JiangLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Sheng WuCenter for Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ling YangDepartment of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ying TianLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaolei LiuLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Avrum GillespieSection of Nephrology, Hypertension, and Kidney Transplantation, Department of Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jin Jun LuoDepartment of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xinghua Mindy ShiDepartment of Computer and Information Sciences, College of Science and Technology at Temple University, Philadelphia, PA, United States.
Huaqing ZhaoCenter for Biostatistics and Epidemiology, Department of Biomedical Education and Data Science, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Laisel MartinezDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Roberto Vazquez-PadronDeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, United States.
Hong WangCenter for Metabolic Disease Research and Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaofeng YangLemole Center for Integrated Lymphatics and Vascular Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Temple University · USUniversity of Miami · USBeloit College · USUniversity of Wisconsin–Madison · US
Funding
CD40 monocyte in chronic kidney diseaseR01DK113775 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2017 to 2021
$3.3MThe roles of miR-155 in regulating atherosclerosis and metabolically healthy obesityR01HL138749 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2017 to 2020
$2.6MIL-35 inhibits gut microbiota-produced uremic toxin-accelerated endothelial cell activationR01HL147565 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI YANG, XIAOFENG · 2019 to 2022
$2.6MLysoPI/GPR55 pathway promotes endothelial activation, vascular inflammation and atherosclerosisR01HL163570 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Xiaofeng Yang · 2023 to 2026
$2.6MAtherogenic roles of complement systemR01HL130233 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI QIN, XUEBIN, WANG, HONG · 2016 to 2019
$2.5MHHcy-induced Inflammatory Monocyte and Macrophage Differentiation in DiabetesR01DK104116 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI WANG, HONG · 2015 to 2019
$2.2MThe Role of Vascular Calprotectin in Arteriovenous Fistula MaturationR01DK132888 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Roberto Irenardo Vazquez Padron · 2022 to 2026
$2.1MDual Role of Lysyl Oxidase in Arteriovenous Fistula FailureR01DK121227 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHIU, YAN-TING E., VAZQUEZ PADRON, ROBERTO IRENARDO · 2019 to 2023
$2.1MDissecting the functional roles of cardiac lymphatics in ischemic heart diseaseR01HL163269 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI XIAOLEI LIU · 2023 to 2026
$1.9MVascular Progenitor Cells in Arteriovenous Fistula StenosisR01DK098511 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI ANDREOPOULOS, FOTIOS MATTHAIOS, SALMAN, LOAY HATEM · 2013 to 2016
$1.5MCellular Mechanisms of Mac-1 Mediated AtheroprotectionK08HL151747 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MARTINEZ, LAISEL · 2020 to 2024
$575kBLRD VA I01 BX004658NHLBI NIH HHS K08 HL151747NHLBI NIH HHS R01 HL130233NHLBI NIH HHS R01 HL138749NHLBI NIH HHS R01 HL147565NHLBI NIH HHS R01 HL163269NHLBI NIH HHS R01 HL163570NIDDK NIH HHS R01 DK098511NIDDK NIH HHS R01 DK104116NIDDK NIH HHS R01 DK113775NIDDK NIH HHS R01 DK121227NIDDK NIH HHS R01 DK132888
Abstract
Introduction: Vascular smooth muscle cells (VSMCs) are the predominant cell type in the medial layer of the aorta, which plays a critical role in aortic diseases. Innate immunity is the main driving force for cardiovascular diseases. Methods: To determine the roles of innate immunity in VSMC and aortic pathologies, we performed transcriptome analyses on aortas from ApoE Results: We made significant findings: Discussion: Our findings have provided novel insights on the roles of innate immune responses and nuclear stresses in the development of AAA, atherosclerosis, and VSMC immunology and provided novel therapeutic targets for treating those significant cardiovascular and cerebrovascular diseases.
Indexed as
Aortic AneurysmAortic Aneurysm, AbdominalAtherosclerosisApolipoproteins ECell TransdifferentiationHumansImmunity, InnateInflammationMuscle, Smooth, VascularNF-kappa BApolipoproteins ENF-kappa Bnuclear stresstrained immunitytrans-differentiationvascular inflammationVSMCs
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