Evidence map›Paper›PMID 38327612›Full record

ArticleResearch and practice in thrombosis and haemostasis2024

Apixaban overdose in children: case report and proposed management. A brief communication from the Pediatric and Neonatal Thrombosis and Hemostasis SSC of ISTH.

Meredith Wiggins, Tina Biss, Leslie Raffini, Heleen Van Ommen, Anthony Chan, Christina Vanderpluym, Neil Goldenberg, Paul Monagle

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meredith WigginsSydney Children's Hospital, Randwick, Sydney, New South Wales, Australia.
Tina BissNewcastle upon Tyne Hospitals, National Health Service Trust, Newcastle upon Tyne, United Kingdom.
Leslie RaffiniDepartment of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Heleen Van OmmenSophia Children's Hospital Erasmus University Medical Center, Rotterdam, The Netherlands.
Anthony ChanDepartment of Pediatrics, McMaster Centre for Transfusion Research, McMaster University, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Christina VanderpluymHeart Center, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Neil GoldenbergDepartments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.
Paul MonagleSydney Children's Hospital, Randwick, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Direct oral anticoagulants are commonly prescribed for adults and increasingly also for children requiring anticoagulation therapy. While household medications should not be accessible to children, accidental, and intentional overdoses occur. Key Clinical Question: How should apixaban overdose in children be managed?. Clinical Approach: We present a case of an accidental overdose with the factor Xa antagonist apixaban in a young child and propose an approach to the management of cases of apixaban overdose in children. Conclusion: Given the increasing use of direct oral anticoagulants, it is important to have an approach to the management of overdose of these medications.

Indexed as

anticoagulantsapixabanchilddrug overdosepediatrics

Identifiers

PMID38327612
PMCPMC10847918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.