Evidence map›Paper›PMID 38327451›Full record

ArticleHeliyon2024

Biological evaluation of novel side chain containing CQTrICh-analogs as antimalarials and their development as

Iram Irfan, Amad Uddin, Ravi Jain, Aashima Gupta, Sonal Gupta, John V Napoleon, Afzal Hussain, Mohamed F Alajmi, Mukesh C Joshi, Phool Hasan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Iram IrfanMedicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Amad UddinMedicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Ravi JainSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Aashima GuptaSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Sonal GuptaSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
John V NapoleonChemistry, Purdue University System, West Lafayette, IN, USA.
Afzal HussainDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohamed F AlajmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mukesh C JoshiDepartment of Chemistry, Kirori Mal College, University of Delhi, Delhi 110007, India.
Phool HasanMedicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Purnendu KumarSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.
Mohammad AbidMedicinal Chemistry Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi, 110025, India.
Shailja SinghSpecial Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110067, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid emergence of resistance to existing frontline antimalarial drugs emphasizes a need for the development of target-oriented molecules with novel modes of action. Given the importance of a plant-like Calcium-Dependent Protein Kinase 1 (

Indexed as

AntimalarialIndole-chalconeKinase inhibitionPfCDPK1Plasmodium falciparum

Identifiers

PMID38327451
PMCPMC10847618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.