Evidence map›Paper›PMID 38327127›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Transcriptomic Signature of 3D Hierarchical Porous Chip Enriched Exosomes for Early Detection and Progression Monitoring of Hepatocellular Carcinoma.

Kezhen Yi, Yike Wang, Yuan Rong, Yiru Bao, Yingxue Liang, Yiyi Chen, Fusheng Liu, Shikun Zhang, Yuan He, Weihuang Liu and 8 more

Open access · goldAbstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

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  11. Extracellular Vesicle Preparation and Analysis: A State-of-the-Art Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Kezhen YiDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, P. R. China.
Yike WangCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Yuan RongDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, P. R. China.
Yiru BaoCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Yingxue LiangCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Yiyi ChenDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, P. R. China.
Fusheng LiuDepartment of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China.
Shikun ZhangDepartment of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China.
Yuan HeMedical Research Center for Structural Biology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Weihuang LiuMedical Research Center for Structural Biology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Chengliang ZhuDepartment of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, P. R. China.
Long WuDepartment of Oncology, Renmin Hospital of Wuhan University, Wuhan, 430060, P. R. China.
Jin PengDepartment of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, P. R. China.
Hao ChenDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P. R. China.
Weihua HuangCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Yufeng YuanDepartment of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, P.R. China.
Min XieCollege of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, P. R. China.
Fubing WangDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University, No.169 Donghu Road, Wuchang District, Wuhan, 430071, P. R. China.ORCID 0000-0002-5971-2622
Wuhan University · CN

Funding

Basic and Clinical Medical Research Joint Fund of Zhongnan Hospital and Wuhan University ZNLH202209Clinical research transformation project of Zhongnan Hospital lcyf202210Creative Research Groups of Hubei Provincial Natural Science Foundation 2022CFA005Key Research and Development Program of Hunan Province of China 2021BCA114National Natural Science Foundation of China 12175167National Natural Science Foundation of China 21974098National Natural Science Foundation of China 22274120
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly lethal malignant tumor, and the current non-invasive diagnosis method based on serum markers, such as α-fetoprotein (AFP), and des-γ-carboxy-prothrombin (DCP), has limited efficacy in detecting it. Therefore, there is a critical need to develop novel biomarkers for HCC. Recent studies have highlighted the potential of exosomes as biomarkers. To enhance exosome enrichment, a silicon dioxide (SiO

Indexed as

Carcinoma, HepatocellularExosomesLiver NeoplasmsRNA, Long Noncodingalpha-FetoproteinsBiomarkers, TumorGene Expression ProfilingHumansPorositySilicon Dioxidealpha-FetoproteinsBiomarkers, TumorRNA, Long NoncodingSilicon Dioxideexosomehepatocellular carcinomaliquid biopsylong noncoding RNAmicrofluidic chips

Identifiers

PMID38327127
PMCPMC11005692
OpenAlexW4391635572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.