Evidence map›Paper›PMID 38327099›Full record

ArticleCurrent protocols2024

Protection-Free, Two-step Synthesis of C5-C Functionalized Pyrimidine Nucleosides.

Karolina Podskoczyj, Anna Kuszczynska, Agnieszka Dziergowska, Grazyna Leszczynska

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current protocols, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Karolina PodskoczyjInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Lodz, Poland.ORCID https://orcid.org/0000-0003-1793-4320
Anna KuszczynskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Lodz, Poland.
Agnieszka DziergowskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Lodz, Poland.
Grazyna LeszczynskaInstitute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Lodz, Poland.ORCID https://orcid.org/0000-0002-6874-022X
Lodz University of Technology · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A simple, reliable, and efficient method for the gram-scale chemical synthesis of pyrimidine nucleosides functionalized with C5-carboxyl, nitrile, ester, amide, or amidine, starting from unprotected uridine and cytidine, is described. The protocol involves the synthesis of 5-trifluoromethyluridine and 5-trifluoromethylcytidine with Langlois reagent (CF

Indexed as

Chemistry, OrganicPyrimidine NucleosidesCytidineRibonucleosidesUridineCytidinePyrimidine NucleosidesRibonucleosidesUridine5-trifluoromethylcytidine5-trifluoromethyluridineC5-modified pyrimidine nucleosidesCF3-group transformationsgram-scale chemical synthesis

Identifiers

PMID38327099
PMCPMC13014064
OpenAlexW4391635621

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.