Evidence map›Paper›PMID 38327010›Full record

ArticleThe British journal of radiology2024

Imaging characterization of paediatric tumours with the neurotrophic tyrosine receptor kinase fusion transcript.

Anne-Laure Hermann, Lauriane Lemelle, Gaëlle Pierron, Arnaud Gauthier, Nayla Nicolas, Liesbeth Cardoen, Salma Moalla, Philippe Petit, Baptiste Morel, Hubert Ducou Le Pointe and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 9 institutions in 1 country.

Anne-Laure HermannDepartment of Imaging, Institut Curie, PSL University, Paris, 75005, France.ORCID 0000-0002-2534-1448
Lauriane LemelleSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France.
Gaëlle PierronDepartment of Somatic Genetics, Institut Curie, PSL University, Paris, 75005, France.ORCID 0000-0002-2536-7680
Arnaud GauthierDepartment of Pathology, Institut Curie, PSL University, Paris, 75005, France.
Nayla NicolasDepartment of Imaging, Institut Curie, PSL University, Paris, 75005, France.
Liesbeth CardoenDepartment of Imaging, Institut Curie, PSL University, Paris, 75005, France.
Salma MoallaDepartment of Imaging, Gustave Roussy Cancer Center, Villejuif, 94805, France.
Philippe PetitDepartment of Imaging, Assistance Publique des Hôpitaux de Marseille, Hôpital de La Timone, Marseille, 13005, France.
Baptiste MorelDepartment of Pediatric Radiology, CHRU Hôpitaux de Tours, Tours, 37000, France.
Hubert Ducou Le PointeDepartment of Pediatric Radiology, Assistance Publique des Hôpitaux de Paris, Hôpital Armand Trousseau, Paris, 75012, France.
Adnan HassaniDepartment of Pediatric Radiology, CHU Rouen, Rouen, 76000, France.
Paul FréneauxDepartment of Pathology, Institut Curie, PSL University, Paris, 75005, France.
Delphine GuillemotDepartment of Somatic Genetics, Institut Curie, PSL University, Paris, 75005, France.
Matthieu CartonDepartment of Biostatistics, Institut Curie, PSL University, Paris, 75005, France.
Nadège CorradiniDepartment of Pediatric Oncology and Hematology, Centre Léon Bérard, Lyon, 69008, France.
Angélique RomeDepartment of Pediatric Oncology, Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Marseille, 13005, France.
Marie-Pierre CastexDepartment of Pediatric Oncology and Hematology, CHU Toulouse, Toulouse, 31300, France.
Anne-Sophie DefachellesDepartment of Pediatric Oncology, Oscar Lambret Center, Lille, 59000, France.
Gudrun SchleiermacherSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France.
Pablo BerlangaDepartment of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, INSERM U1015, Université Paris-Saclay, Villejuif, 94805, France.
Olivier DelattreSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France.
Daniel OrbachSIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France.ORCID 0000-0002-2520-139X
Hervé J BrisseDepartment of Imaging, Institut Curie, PSL University, Paris, 75005, France.
Université Paris Sciences et Lettres · FRHôpital de la Timone · FRCentre Hospitalier Universitaire de Rouen · FRCentre Hospitalier Universitaire de Tours · FRCentre Léon Bérard · FRCentre Oscar Lambret · FRInserm · FRInstitut Gustave Roussy · FRSorbonne Université · FR

Funding

BayerFrench society for childhood and adolescent cancers and leukemiasImagine for Margo
6 · The paper itself

Abstract

objectivesThe neurotrophic tyrosine receptor kinase (NTRK) fusion transcript (FT) is a major genetic landmark of infantile fibrosarcoma (IFS) and cellular congenital mesoblastic nephroma (cCMN) but is also described in other tumours. The recent availability of NTRK-targeted drugs enhances the need for better identification. We aimed to describe the anatomic locations and imaging features of tumours with NTRK-FT in children. CASE SERIES: Imaging characteristics of NTRK-FT tumours of 41 children (median age: 4 months; 63% <1 year old; range: 0-188) managed between 2001 and 2019 were retrospectively analysed. The tumours were located in the soft tissues (n = 24, including 19 IFS), kidneys (n = 9, including 8 cCMN), central nervous system (CNS) (n = 5), lung (n = 2), and bone (n = 1). The tumours were frequently deep-located (93%) and heterogeneous (71%) with necrotic (53%) or haemorrhagic components (29%). Although inconstant, enlarged intratumoural vessels were a recurrent finding (70%) with an irregular distribution (63%) in the most frequent anatomical locations.

conclusionPaediatric NTRK-FT tumours mainly occur in infants with very variable histotypes and locations. Rich and irregular intra-tumoural vascularization are recurrent findings. ADVANCES IN KNOWLEDGE: Apart from IFS of soft tissues and cCMN of the kidneys, others NTRK-FT tumours locations have to be known, as CNS tumours. Better knowledge of the imaging characteristics may help guide the pathological and biological identification.

Indexed as

FibrosarcomaKidney NeoplasmsNephroma, MesoblasticReceptors, Amino AcidChildHumansInfantRetrospective StudiesReceptors, Amino Acidtyrosine receptorcellular congenital mesoblastic nephromafusion transcript tumourinfantile fibrosarcomaMRIneurotrophic tyrosine receptor kinase

Identifiers

PMID38327010
PMCPMC11027258
OpenAlexW4390938137

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.