Evidence map›Paper›PMID 38326876›Full record

ReviewEuropean journal of medical research2024

Koetjapic acid: unveiling its potential as a saviour in the realm of biological and medicinal properties, with a focus on anticancer mechanism of action.

Muhammad Armaghan, Khushbukhat Khan, Muhammad Irfan, Amna Hafeez, Sameen Zafar, Zeeshan Javed, Javad Sharifi-Rad, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Muhammad ArmaghanAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Khushbukhat KhanAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan. khushi-khan2011@hotmail.com.
Muhammad IrfanAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Amna HafeezAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Sameen ZafarAtta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.
Zeeshan JavedOffice for Research Innovation and Commercialization (ORIC), Lahore Garrison University, Sector-C, DHA Phase-VI, Lahore, Pakistan.
Javad Sharifi-RadFacultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad@uazuay.edu.ec.
Monica ButnariuUniversity of Life Sciences ''King Mihai I'' from Timisoara, 300645, Calea Aradului 119, Timis, Romania. monicabutnariu@yahoo.com.
Ioan SaracUniversity of Life Sciences ''King Mihai I'' from Timisoara, 300645, Calea Aradului 119, Timis, Romania.
Iulia-Cristina BagiuVictor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.
Radu Vasile BagiuVictor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania.
National University of Sciences and Technology · PKVictor Babeș University of Medicine and Pharmacy Timișoara · ROLahore Garrison University · PKNational University of Technology · PKUniversidad del Azuay · ECUnivesity of Life Science "King Mihai I" from Timisoara · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scientists have been compelled to search for alternative treatments due to the increasing prevalence of chemoresistance as well as the agonising and distressing side effects of both chemotherapy and radiation. Plant extracts have been exploited to treat various medical conditions for ages. Considering this fact, the main focus of various recent studies that are being conducted to find new and potent anticancer drugs involves the identification and utilisation of potential therapeutic chemicals present in plant extracts. Koetjapic acid (KJA), which belongs to the family of triterpenes, is primarily isolated from Sandoricum koetjape. Ongoing investigations into its therapeutic applications have revealed its tendency to impede the growth and proliferation of cancer cells. Koetjapic acid activates the intrinsic apoptotic pathway and promotes the death of cancer cells. Moreover, it inhibits angiogenesis and the dissemination of tumour (metastasis) by targeting the VEGF signalling cascade. Therefore, this study aims to elucidate the underlying mechanism of anticancer activity of koetjapic acid, providing significant insight into the compound's potential as an anticancer agent.

Indexed as

Antineoplastic AgentsTriterpenesApoptosisHumansPlant ExtractsAntineoplastic Agentskoetjapic acidPlant ExtractsTriterpenesAngiogenesisApoptosisCancerKoetjapic acidNatural compounds

Identifiers

PMID38326876
PMCPMC10848377
OpenAlexW4391613506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.