Evidence map›Paper›PMID 38326787›Full record

ArticleBMC infectious diseases2024

Ocular syphilis masquerading as refractory retinal diseases.

Sung Who Park, Kye-Hyung Kim, Han Jo Kwon, Ik Soo Byon, Youan Hasan Khan, Quan Dong Nguyen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sung Who ParkDepartment of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.
Kye-Hyung KimDepartment of Infection, School of Medicine, Pusan National University, Busan, South Korea.
Han Jo KwonDepartment of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.
Ik Soo ByonDepartment of Ophthalmology, School of Medicine, Pusan National University, Busan, South Korea.
Youan Hasan KhanSpencer Center for Vision Research, Byers Eye Institute, Stanford University, 2370 Watson Court, Suite 200, Palo Alto, CA, 94303, USA.
Quan Dong NguyenSpencer Center for Vision Research, Byers Eye Institute, Stanford University, 2370 Watson Court, Suite 200, Palo Alto, CA, 94303, USA. ndquan@stanford.edu.
Pusan National University · KRPusan National University Hospital · KRStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report two cases of syphilis masquerading as chronic refractory macular diseases. CASE DESCRIPTIONS: Two patients had been diagnosed with neovascular age-related macular degeneration (neovascular AMD) and diabetic macular edema (DME), respectively. The disease worsened despite repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) and also surgical treatment (in suspected case of DME). Systemic evaluations were positive for syphilis. Intravenous penicillin was started, and the macular diseases improved. The lesions were well controlled afterward.

conclusionsThe current two cases demonstrated that ocular syphilis can masquerade as refractory chronic retinal diseases such as DME and neovascular AMD. Laboratory evaluations for syphilis may be needed, not only for uveitis but also for refractory retinal diseases. Indocyanine green angiography may be helpful to reveal occult syphilis.

Indexed as

Choroidal NeovascularizationDiabetic RetinopathyEndophthalmitisMacular EdemaSyphilisWet Macular DegenerationAngiogenesis InhibitorsHumansIntravitreal InjectionsVascular Endothelial Growth Factor AVisual AcuityAngiogenesis InhibitorsVascular Endothelial Growth Factor AAge related macular degenerationChoroidal neovascularizationDiabetic macular edemaLatent syphilisOcular syphilisSyphilis

Identifiers

PMID38326787
PMCPMC10848460
OpenAlexW4391613564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.