Evidence map›Paper›PMID 38326776›Full record

ArticleBMC infectious diseases2024

Maternal sepsis and factors associated with poor maternal outcomes in a tertiary hospital in Tigray, Ethiopia: a retrospective chart review.

Bisrat Tesfay Abera, Hale Teka, Daniel Gebre, Tsega Gebremariam, Ephrem Berhe, Hagos Gidey, Birhane Amare, Rahel Kidanemariam, Marta Abrha Gebru, Fireweyni Tesfay and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 2 countries.

Bisrat Tesfay AberaDepartment of Internal Medicine, School of Medicine, Mekelle University, Box: 1871, Mekelle, Tigray, Ethiopia. bis9live@gmail.com.ORCID http://orcid.org/0000-0002-7227-2254
Hale TekaDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Daniel GebreDepartment of Midwifery, Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia.
Tsega GebremariamDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Ephrem BerheDepartment of Internal Medicine, School of Medicine, Mekelle University, Box: 1871, Mekelle, Tigray, Ethiopia.
Hagos GideyDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Birhane AmareDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Rahel KidanemariamDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Marta Abrha GebruDepartment of Internal Medicine, School of Medicine, Mekelle University, Box: 1871, Mekelle, Tigray, Ethiopia.
Fireweyni TesfayDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Yibrah Berhe ZelelowDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Awol YemaneDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Fanus GebruDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Ashenafi TekleDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Habtom TadesseDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Mohammedtahir YahyaDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Ytbarek TadesseDepartment of Obstetrics and Gynecology, School of Medicine, Mekelle University, Mekelle, Tigray, Ethiopia.
Hiluf Ebuy AbrahaDepartment of Biostatistics, School of Public Health, Mekelle University, Mekelle, Tigray, Ethiopia.
Mussie AlemayehuDepartment of Reproductive Health, School of Public Health, Mekelle University, Mekelle, Tigray, Ethiopia.
Mohamedawel Mohamedniguss EbrahimDepartment of Biostatistics, School of Public Health, Mekelle University, Mekelle, Tigray, Ethiopia.
Mekelle University · ETUniversity of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal sepsis is the third leading cause of maternal death in the world. Women in resource-limited countries shoulder most of the burdens related to sepsis. Despite the growing risk associated with maternal sepsis, there are limited studies that have tried to assess the impact of maternal sepsis in resource-limited countries. The current study determined the outcomes of maternal sepsis and factors associated with having poor maternal outcomes.

methodsA facility-based retrospective cross-sectional study design was employed to assess the clinical presentation, maternal outcomes, and factors associated with maternal sepsis. The study was conducted in Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia, from January 1, 2017, to December 31, 2021. Sociodemographic characteristics, clinical characteristics and outcomes of women with maternal sepsis were analyzed using a descriptive statistic. The association between dependent and independent variables was determined using multivariate logistic regression.

resultsAmong 27,350 live births, 298 mothers developed sepsis, giving a rate of 109 maternal sepsis for every 10,000 live births. There were 22 maternal deaths, giving rise to a case fatality rate of 7.4% and a maternal mortality ratio of 75 per 100,000 live births. Admission to the intensive care unit and use of mechanical ventilator were observed in 23.5% and 14.1% of the study participants, respectively. A fourth (24.2%) of the mothers were complicated with septic shock. Overall, 24.2% of women with maternal sepsis had severe maternal outcomes (SMO). Prolonged hospital stay, having parity of two and above, having the lung as the focus of infection, switchof antibiotics, and developing septic shock were significantly associated with SMO.

conclusionsThis study revealed that maternal sepsis continues to cause significant morbidity and mortality in resource-limited settings; with a significant number of women experiencing death, intensive care unit admission, and intubation attributable to sepsis. The unavailability of recommended diagnostic modalities and management options has led to the grave outcomes observed in this study. To ward off the effects of infection during pregnancy, labor and postpartum period and to prevent progression to sepsis and septic shock in low-income countries, we recommend that concerted and meticulous efforts should be applied to build the diagnostic capacity of health facilities, to have effective infection prevention and control practice, and to avail recommended diagnostic and management options.

Indexed as

Maternal DeathPre-EclampsiaPregnancy Complications, InfectiousSepsisShock, SepticCross-Sectional StudiesEthiopiaFemaleHumansMaternal MortalityPregnancyRetrospective StudiesTertiary Care CentersAssociated factorsEthiopiaMaternal sepsisSevere maternal outcomesTigray

Identifiers

PMID38326776
PMCPMC10848478
OpenAlexW4391614367

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.