Evidence map›Paper›PMID 38326745›Full record

ArticleBMC immunology2024

Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients.

Cui Li, Haiyan Liu, Zhongliang Duan

Open access · goldAbstract read
In one paragraph

Article in BMC immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Immune checkpoint for pregnancy.Seminars in immunopathology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cui LiClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200011, China.
Haiyan LiuObstetrics Department, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Zhongliang DuanClinical Laboratory, Obstetrics and Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200011, China. zduan12@fudan.edu.cn.
Obstetrics and Gynecology Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China 82102469
6 · The paper itself

Abstract

backgroundImbalanced immune responses are involved in developing preeclampsia (PE). We wish to explore the expression and potential changes of immune checkpoint molecules TIGIT, CD226 and CD155 in PE patients.

methodsThe expression of the immune checkpoint molecules TIGIT, CD226 and CD155 in different lymphocyte subpopulations was determined by flow cytometry in 24 patients with PE and compared to 24 healthy pregnant women of the same gestational age as the controls.​Serum CD155 was detected by ELISA in the patients with PE compared to controls.

resultsThe percentages of CD4

conclusionThe immune checkpoint molecules TIGIT, CD226 and CD155 are not abnormally expressed in PE patients.

Indexed as

CD8-Positive T-LymphocytesPre-EclampsiaAntigens, Differentiation, T-LymphocyteFemaleHumansImmune Checkpoint ProteinsPregnancyReceptors, ImmunologicAntigens, Differentiation, T-LymphocyteImmune Checkpoint ProteinsReceptors, ImmunologicTIGIT protein, humanCD155CD226PreeclampsiaTIGIT

Identifiers

PMID38326745
PMCPMC10848455
OpenAlexW4391613507

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.