Evidence map›Paper›PMID 38326736›Full record

ArticleBMC cardiovascular disorders2024

Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers.

Abhishek Dattani, Emer M Brady, Prathap Kanagala, Svetlana Stoma, Kelly S Parke, Anna-Marie Marsh, Anvesha Singh, Jayanth R Arnold, Alastair J Moss, Lei Zhao and 15 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03050593 (Prospective, Observational, Single-centre, Cohort Study Aimed at Developing Imaging and Plasma Biomarkers in Heart Failure With Preserved Ejection Fraction), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03050593 completednot on this map

Prospective, Observational, Single-centre, Cohort Study Aimed at Developing Imaging and Plasma Biomarkers in Heart Failure With Preserved Ejection Fraction

TypeobservationalSponsorUniversity of LeicesterRan2013 to 2015Enrolled280ConditionsPatients With Heart Failure and Preserved Ejection Fraction - HFpEF, Patients With Heart Failure With Reduced Ejection Fraction - HFrEF, Healthy Controls Group - Age and Sex-matchedArmsMRI scan, Echo scan
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 5 institutions in 2 countries.

Abhishek DattaniDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK. ad530@leicester.ac.uk.
Emer M BradyDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Prathap KanagalaUniversity of Liverpool, Liverpool, UK.
Svetlana StomaDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Kelly S ParkeDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Anna-Marie MarshDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Anvesha SinghDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Jayanth R ArnoldDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Alastair J MossDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Lei ZhaoBristol Myers Squibb, Princeton, NJ, USA.
Mary Ellen CvijicBristol Myers Squibb, Princeton, NJ, USA.
Matthew FronheiserBristol Myers Squibb, Princeton, NJ, USA.
Shuyan DuBristol Myers Squibb, Princeton, NJ, USA.
Philippe CostetBristol Myers Squibb, Princeton, NJ, USA.
Peter SchaferBristol Myers Squibb, Princeton, NJ, USA.
Leon CarayannopoulosBristol Myers Squibb, Princeton, NJ, USA.
Ching-Pin ChangBristol Myers Squibb, Princeton, NJ, USA.
David GordonBristol Myers Squibb, Princeton, NJ, USA.
Francisco Ramirez-ValleBristol Myers Squibb, Princeton, NJ, USA.
Michael Jerosch-HeroldBrigham and Women's Hospital and Harvard Medical School, Boston, USA.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Iain B SquireDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Leong L NgDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
Bristol-Myers Squibb (United States) · USNational Institute for Health Research · GBUniversity of Leicester · GBHarvard University · USUniversity of Liverpool · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) frequently co-exist. There is a limited understanding on whether this coexistence is associated with distinct alterations in myocardial remodelling and mechanics. We aimed to determine if patients with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) represent a distinct phenotype.

methodsIn this secondary analysis of adults with HFpEF (NCT03050593), participants were comprehensively phenotyped with stress cardiac MRI, echocardiography and plasma fibroinflammatory biomarkers, and were followed for the composite endpoint (HF hospitalisation or death) at a median of 8.5 years. Those with AF were compared to sinus rhythm (SR) and unsupervised cluster analysis was performed to explore possible phenotypes.

results136 subjects were included (SR = 75, AF = 61). The AF group was older (76 ± 8 vs. 70 ± 10 years) with less diabetes (36% vs. 61%) compared to the SR group and had higher left atrial (LA) volumes (61 ± 30 vs. 39 ± 15 mL/m

conclusionsPresence of AF in HFpEF is associated with cardiac structural and functional changes together with altered expression of several fibro-inflammatory biomarkers. Distinct phenotypes exist in HFpEF which may have differing clinical outcomes.

Indexed as

Atrial FibrillationHeart FailureMultiparametric Magnetic Resonance ImagingAdultBiomarkersHumansMatrix Metalloproteinase 2PhenotypePrognosisStroke VolumeVentricular Function, LeftBiomarkersMatrix Metalloproteinase 2Atrial fibrillationBiomarkersCardiovascular magnetic resonanceCluster analysisHeart failurePhenotype

Identifiers

PMID38326736
PMCPMC10848361
OpenAlexW4391613882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.